Department of Anesthesiology
Author Title [ Type(Asc)] Year
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Journal Article
Lolicato M, Riegelhaupt PM, Arrigoni C, Clark KA, Minor DL.  2014.  Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels.. Neuron. 84(6):1198-212.
Hemmings HC, Riegelhaupt PM, Kelz MB, Solt K, Eckenhoff RG, Orser BA, Goldstein PA.  2019.  Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery.. Trends Pharmacol Sci. 40(7):464-481.
Riegelhaupt PM, Hemmings HC, Goldstein PA.  2016.  Relevance of Clinical Relevance.. Anesthesiology. 125(4):821-2.
Schmidpeter PAM, Petroff JT, Khajoueinejad L, Wague A, Frankfater C, Cheng WWL, Nimigean CM, Riegelhaupt PM.  2023.  Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.. Nat Commun. 14(1):1077.
Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia BA, Nimigean CM, Eckenhoff RG, Riegelhaupt PM.  2020.  Mechanistic insights into volatile anesthetic modulation of K2P channels.. Elife. 9
Riegelhaupt PM, Tibbs GR, Goldstein PA.  2018.  HCN and K Channels in Anesthetic Mechanisms Research.. Methods Enzymol. 602:391-416.
Riel EB, Bu W, Joseph TT, Khajoueinejad L, Eckenhoff RG, Riegelhaupt PM.  2025.  The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel.. Proc Natl Acad Sci U S A. 122(14):e2421654122.
J Chazen L, Sarva H, Stieg PE, Min RJ, Ballon DJ, Pryor KO, Riegelhaupt PM, Kaplitt MG.  2017.  Clinical improvement associated with targeted interruption of the cerebellothalamic tract following MR-guided focused ultrasound for essential tremor.. J Neurosurg. :1-9.
Schmidpeter PAM, Wu D, Rheinberger J, Riegelhaupt PM, Tang H, Robinson CV, Nimigean CM.  2022.  Anionic lipids unlock the gates of select ion channels in the pacemaker family.. Nat Struct Mol Biol. 29(11):1092-1100.