Pfizer COVID-19 vaccine appointments are available to our patients. Sign up for Connect today to schedule your vaccination. Continue your routine care with us by scheduling an in-person appointment or Video Visit.

HCN and K Channels in Anesthetic Mechanisms Research.

TitleHCN and K Channels in Anesthetic Mechanisms Research.
Publication TypeJournal Article
Year of Publication2018
AuthorsRiegelhaupt PM, Tibbs GR, Goldstein PA
JournalMethods Enzymol
Date Published2018

The ability of a diverse group of agents to produce general anesthesia has long been an area of intense speculation and investigation. Over the past century, we have seen a paradigm shift from proposing that the anesthetized state arises from nonspecific interaction of anesthetics with the lipid membrane to the recognition that the function of distinct, and identifiable, membrane-embedded proteins is dramatically altered in the presence of intravenous and inhaled agents. Among proteinaceous targets, metabotropic and ionotropic receptors garnered much of the attention over the last 30 years, and it is only relatively recently that voltage-gated ion channels have clearly and rigorously been shown to be important molecular targets. In this review, we will consider the experimental issues relevant to two important ion channel anesthetic targets, HCN and K.

Alternate JournalMeth. Enzymol.
PubMed ID29588040