Department of Anesthesiology

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HCN and K Channels in Anesthetic Mechanisms Research.

TitleHCN and K Channels in Anesthetic Mechanisms Research.
Publication TypeJournal Article
Year of Publication2018
AuthorsRiegelhaupt PM, Tibbs GR, Goldstein PA
JournalMethods Enzymol
Volume602
Pagination391-416
Date Published2018
ISSN1557-7988
Abstract

The ability of a diverse group of agents to produce general anesthesia has long been an area of intense speculation and investigation. Over the past century, we have seen a paradigm shift from proposing that the anesthetized state arises from nonspecific interaction of anesthetics with the lipid membrane to the recognition that the function of distinct, and identifiable, membrane-embedded proteins is dramatically altered in the presence of intravenous and inhaled agents. Among proteinaceous targets, metabotropic and ionotropic receptors garnered much of the attention over the last 30 years, and it is only relatively recently that voltage-gated ion channels have clearly and rigorously been shown to be important molecular targets. In this review, we will consider the experimental issues relevant to two important ion channel anesthetic targets, HCN and K.

DOI10.1016/bs.mie.2018.01.015
Alternate JournalMeth. Enzymol.
PubMed ID29588040