Title | Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Hemmings HC, Riegelhaupt PM, Kelz MB, Solt K, Eckenhoff RG, Orser BA, Goldstein PA |
Journal | Trends Pharmacol Sci |
Volume | 40 |
Issue | 7 |
Pagination | 464-481 |
Date Published | 2019 Jul |
ISSN | 1873-3735 |
Abstract | Significant progress has been made in the 21st century towards a comprehensive understanding of the mechanisms of action of general anesthetics, coincident with progress in structural biology and molecular, cellular, and systems neuroscience. This review summarizes important new findings that include target identification through structural determination of anesthetic binding sites, details of receptors and ion channels involved in neurotransmission, and the critical roles of neuronal networks in anesthetic effects on memory and consciousness. These recent developments provide a comprehensive basis for conceptualizing pharmacological control of amnesia, unconsciousness, and immobility. |
DOI | 10.1016/j.tips.2019.05.001 |
Alternate Journal | Trends Pharmacol. Sci. |
PubMed ID | 31147199 |
Grant List | R01 GM088156 / GM / NIGMS NIH HHS / United States |
Pfizer COVID-19 vaccine appointments are available to our patients. Sign up for Connect today to schedule your vaccination. Continue your routine care with us by scheduling an in-person appointment or Video Visit.