When the TMEM16F protein is active, the protein subunits (green/red and white) rearrange their configurations, leading to an X-shaped groove that forms a pore through the membrane. This change also makes the membrane thinner, allowing for lipid molecules (yellow) to be transported or “scrambled.” Image provided by the Accardi lab.
Weill Cornell Medicine investigators have revealed the detailed workings of a cell membrane protein that has essential roles in all animals....
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