Department of Anesthesiology
Author Title [ Type(Desc)] Year
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Journal Article
Zhao W, Zhang M, Liu J, Liang P, Wang R, Hemmings HC, Zhou C.  2019.  Isoflurane Modulates Hippocampal Cornu Ammonis Pyramidal Neuron Excitability by Inhibition of Both Transient and Persistent Sodium Currents in Mice.. Anesthesiology. 131(1):94-104.
Platholi J, Herold KF, Hemmings HC, Halpain S.  2014.  Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism.. PLoS One. 9(7):e102978.
Zhao W, Zhao S, Zhu T, Ou M, Zhang D, Sun H, Liu J, Chen X, Hemmings HC, Zhou C.  2021.  Isoflurane Suppresses Hippocampal High-frequency Ripples by Differentially Modulating Pyramidal Neurons and Interneurons in Mice.. Anesthesiology.
Ouyang W, Hemmings HC.  2007.  Isoform-selective effects of isoflurane on voltage-gated Na+ channels.. Anesthesiology. 107(1):91-8.
Platholi J, Hemmings HC.  2021.  Modulation of dendritic spines by protein phosphatase-1.. Adv Pharmacol. 90:117-144.
Hemmings HC.  2004.  Neuroprotection by Na+ channel blockade.. J Neurosurg Anesthesiol. 16(1):100-1.
Perouansky M, Hemmings HC.  2009.  Neurotoxicity of general anesthetics: cause for concern? Anesthesiology. 111(6):1365-71.
Eger EI, Raines DE, Shafer SL, Hemmings HC, Sonner JM.  2008.  Is a new paradigm needed to explain how inhaled anesthetics produce immobility? Anesth Analg. 107(3):832-48.
Hemmings HC.  2007.  Noble meets nouveau: a shared anesthetic binding site for xenon and isoflurane on a glutamate receptor.. Anesthesiology. 107(5):694-6.
Eastman RT, Rusinova R, Herold KF, Huang X-P, Dranchak P, Voss TC, Rana S, Shrimp JH, White AD, Hemmings HC et al..  2023.  Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity.. bioRxiv.
Hotte M, Thuault S, Dineley KT, Hemmings HC, Nairn AC, Jay TM.  2007.  Phosphorylation of CREB and DARPP-32 during late LTP at hippocampal to prefrontal cortex synapses in vivo.. Synapse. 61(1):24-8.
Futter M, Uematsu K, Bullock SA, Kim Y, Hemmings HC, Nishi A, Greengard P, Nairn AC.  2005.  Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5).. Proc Natl Acad Sci U S A. 102(9):3489-94.
Ingólfsson HI, Thakur P, Herold KF, E Hobart A, Ramsey NB, Periole X, de Jong DH, Zwama M, Yilmaz D, Hall K et al..  2014.  Phytochemicals perturb membranes and promiscuously alter protein function.. ACS Chem Biol. 9(8):1788-98.
Hemmings HC, Greengard P.  2010.  Positively active: how local anesthetics work.. Anesthesiology. 113(1):250-2.
Zhang TT, Platholi J, Heerdt PM, Hemmings HC, Tung HYL.  2008.  Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation.. Metab Brain Dis. 23(1):95-104.
Morrow PW, Tung HYLim, Hemmings HC.  2004.  Rapamycin causes activation of protein phosphatase-2A1 and nuclear translocation of PCNA in CD4+ T cells.. Biochem Biophys Res Commun. 323(2):645-51.
Westphalen RI, Yu J, Krivitski M, Jih T-Y, Hemmings HC.  2010.  Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS.. J Neurochem. 113(6):1611-20.
Westphalen RI, Kwak N-B, Daniels K, Hemmings HC.  2011.  Regional differences in the effects of isoflurane on neurotransmitter release.. Neuropharmacology. 61(4):699-706.
Platholi J, Federman A, Detert JA, Heerdt P, Hemmings HC.  2014.  Regulation of protein phosphatase 1I by Cdc25C-associated kinase 1 (C-TAK1) and PFTAIRE protein kinase.. J Biol Chem. 289(34):23893-900.
Nguyen C, Nishi A, Kansy JW, Fernandez J, Hayashi K, Gillardon F, Hemmings HC, Nairn AC, Bibb JA.  2007.  Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5.. J Biol Chem. 282(22):16511-20.
Riegelhaupt PM, Hemmings HC, Goldstein PA.  2016.  Relevance of Clinical Relevance.. Anesthesiology. 125(4):821-2.
Speigel IA, Hemmings HC.  2021.  Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review.. Front Synaptic Neurosci. 13:812905.
Hemmings HC, Mackie K.  2011.  The rivers of Lethe and Mnemosyne converge: propofol and memory consolidation.. Anesthesiology. 114(6):1277-9.
Koyanagi Y, Torturo CL, Cook DC, Zhou Z, Hemmings HC.  2019.  Role of specific presynaptic calcium channel subtypes in isoflurane inhibition of synaptic vesicle exocytosis in rat hippocampal neurones.. Br J Anaesth.
Westphalen RI, Hemmings HC.  2003.  Selective depression by general anesthetics of glutamate versus GABA release from isolated cortical nerve terminals.. J Pharmacol Exp Ther. 304(3):1188-96.