Department of Anesthesiology
Author Title [ Type(Desc)] Year
Filters: Keyword is Ion Channel Gating  [Clear All Filters]
Journal Article
Türkaydin B, Schewe M, Riel EBarbara, Schulz F, Biedermann J, Baukrowitz T, Sun H.  2024.  Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels.. Nat Commun. 15(1):4628.
Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM.  2025.  Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel.. Nat Commun. 16(1):1769.
Nimigean CM, Magleby KL.  1999.  The beta subunit increases the Ca2+ sensitivity of large conductance Ca2+-activated potassium channels by retaining the gating in the bursting states.. J Gen Physiol. 113(3):425-40.
Moss BL, Silberberg SD, Nimigean CM, Magleby KL.  1999.  Ca2+-dependent gating mechanisms for dSlo, a large-conductance Ca2+-activated K+ (BK) channel.. Biophys J. 76(6):3099-117.
Zadek B, Nimigean CM.  2006.  Calcium-dependent gating of MthK, a prokaryotic potassium channel.. J Gen Physiol. 127(6):673-85.
Lyashchenko AK, Redd KJ, Goldstein PA, Tibbs GR.  2014.  cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.. PLoS One. 9(7):e101236.
Pusch M, Zifarelli G, Murgia AR, Picollo A, Babini E.  2006.  Channel or transporter? The CLC saga continues. Exp Physiol. 91(1):149-52.
Accardi A, Pusch M.  2003.  Conformational changes in the pore of CLC-0.. J Gen Physiol. 122(3):277-93.
Estévez R, Schroeder BC, Accardi A, Jentsch TJ, Pusch M.  2003.  Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1.. Neuron. 38(1):47-59.
Ouyang W, Hemmings HC.  2005.  Depression by isoflurane of the action potential and underlying voltage-gated ion currents in isolated rat neurohypophysial nerve terminals.. J Pharmacol Exp Ther. 312(2):801-8.
Ratnakumari L, Vysotskaya TN, Duch DS, Hemmings HC.  2000.  Differential effects of anesthetic and nonanesthetic cyclobutanes on neuronal voltage-gated sodium channels.. Anesthesiology. 92(2):529-41.
Pan Y, Pohjolainen E, Schmidpeter PAM, Vaiana AC, Nimigean CM, Grubmüller H, Scheuring S.  2023.  Discrimination between cyclic nucleotides in a cyclic nucleotide-gated ion channel.. Nat Struct Mol Biol. 30(4):512-520.
Herold KF, Andersen OS, Hemmings HC.  2017.  Divergent effects of anesthetics on lipid bilayer properties and sodium channel function.. Eur Biophys J. 46(7):617-626.
Nimigean CM, Chappie JS, Miller C.  2003.  Electrostatic tuning of ion conductance in potassium channels.. Biochemistry. 42(31):9263-8.
Nimigean CM, Magleby KL.  2000.  Functional coupling of the beta(1) subunit to the large conductance Ca(2+)-activated K(+) channel in the absence of Ca(2+). Increased Ca(2+) sensitivity from a Ca(2+)-independent mechanism.. J Gen Physiol. 115(6):719-36.
Gao X, Schmidpeter PAM, Berka V, Durham RJ, Fan C, Jayaraman V, Nimigean CM.  2022.  Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.. Nat Commun. 13(1):6919.
Zifarelli G, Liantonio A, Gradogna A, Picollo A, Gramegna G, De Bellis M, Murgia AR, Babini E, D Camerino C, Pusch M.  2010.  Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels.. Br J Pharmacol. 160(7):1652-61.
Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA.  2005.  Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol.. J Pharmacol Exp Ther. 315(2):517-25.
Ratnakumari L, Hemmings HC.  1996.  Inhibition by propofol of [3H]-batrachotoxinin-A 20-alpha-benzoate binding to voltage-dependent sodium channels in rat cortical synaptosomes.. Br J Pharmacol. 119(7):1498-504.
Neelsen LC, Riel EB, Rinné S, Schmid F-R, Jürs BC, Bedoya M, Langer JP, Eymsh B, Kiper AK, Cordeiro S et al..  2024.  Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2.. Nat Commun. 15(1):7545.
Ouyang W, Jih T-Y, Zhang T-T, Correa AM, Hemmings HC.  2007.  Isoflurane inhibits NaChBac, a prokaryotic voltage-gated sodium channel.. J Pharmacol Exp Ther. 322(3):1076-83.
Ouyang W, Hemmings HC.  2007.  Isoform-selective effects of isoflurane on voltage-gated Na+ channels.. Anesthesiology. 107(1):91-8.
McCoy JG, Rusinova R, Kim DM, Kowal J, Banerjee S, Cartagena AJaramillo, Thompson AN, Kolmakova-Partensky L, Stahlberg H, Andersen OS et al..  2014.  A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics.. J Biol Chem. 289(14):9535-46.
Kowal J, Chami M, Baumgartner P, Arheit M, Chiu P-L, Rangl M, Scheuring S, Schröder GF, Nimigean CM, Stahlberg H.  2014.  Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1.. Nat Commun. 5:3106.
Cheng WWL, McCoy JG, Thompson AN, Nichols CG, Nimigean CM.  2011.  Mechanism for selectivity-inactivation coupling in KcsA potassium channels.. Proc Natl Acad Sci U S A. 108(13):5272-7.