The effects of cocaine on dietary self-selection in female rats.

TitleThe effects of cocaine on dietary self-selection in female rats.
Publication TypeJournal Article
Year of Publication1993
AuthorsBane AJ, McCoy JG, Stump BS, Avery DD
JournalPhysiol Behav
Date Published1993 Sep
KeywordsAnimals, Body Weight, Cocaine, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, Dose-Response Relationship, Drug, Energy Intake, Female, Food Preferences, Rats, Rats, Sprague-Dawley

Cocaine was administered via an oral route to 18-h food deprived female rats for 14 consecutive days. Following administration of the drug or vehicle control each animal was presented with separate isocaloric rations of protein, fat, and carbohydrate in a dietary self-selection situation. Amounts consumed of each component were measured at 30 min, 60 min, 2 h, and 6 h following the drug treatment. The intake of all three macronutrients was suppressed by cocaine for 1 h. Between 2 and 6 h after administration, there was a compensatory increase in fat and carbohydrate, but not protein consumption. The results are discussed in terms of protein deficiency caused by cocaine in pregnant and/or lactating females being a causal factor in the deleterious effects on offspring.

Alternate JournalPhysiol. Behav.
PubMed ID8415945