Publications | Department of Anesthesiology

Department of Anesthesiology

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Journal Article

Accardi A. 2014. Unveiling the secret lives of glutamate transporters: VGLUTs engage in multiple transport modes.. Neuron. 84(6):1110-2.

Walden M, Accardi A, Wu F, Xu C, Williams C, Miller C. 2007. Uncoupling and turnover in a Cl-/H+ exchange transporter.. J Gen Physiol. 129(4):317-29.

Accardi A. 2008. To ATP or not to ATP: this is the question.. J Gen Physiol. 131(2):105-8.

Picollo A, Malvezzi M, Accardi A. 2015. TMEM16 proteins: unknown structure and confusing functions.. J Mol Biol. 427(1):94-105.

Picollo A, Xu Y, Johner N, Bernèche S, Accardi A. 2012. Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H(+)/Cl(-) exchanger.. Nat Struct Mol Biol. 19(5):525-31,S1.

Accardi A, Lobet S, Williams C, Miller C, Dutzler R. 2006. Synergism between halide binding and proton transport in a CLC-type exchanger.. J Mol Biol. 362(4):691-9.

Accardi A. 2015. Structure and gating of CLC channels and exchangers.. J Physiol. 593(18):4129-38.

Accardi A, Walden M, Nguitragool W, Jayaram H, Williams C, Miller C. 2005. Separate ion pathways in a Cl-/H+ exchanger.. J Gen Physiol. 126(6):563-70.

Accardi A, Miller C. 2004. Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels.. Nature. 427(6977):803-7.

Fortea E, Accardi A. 2021. A quantitative flux assay for the study of reconstituted Cl- channels and transporters.. Methods Enzymol. 652:243-272.

Terashima H, Picollo A, Accardi A. 2013. Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels.. Proc Natl Acad Sci U S A. 110(48):19354-9.

Picollo A, Malvezzi M, Accardi A. 2010. Proton block of the CLC-5 Cl-/H+ exchanger.. J Gen Physiol. 135(6):653-9.

Basilio D, Accardi A. 2015. A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters.. J Vis Exp. (98)

Vien M, Basilio D, Leisle L, Accardi A. 2017. Probing the conformation of a conserved glutamic acid within the Cl(-) pathway of a CLC H(+)/Cl(-) exchanger.. J Gen Physiol. 149(4):523-529.

Ying S-W, Tibbs GR, Picollo A, Abbas SY, R Sanford L, Accardi A, Hofmann F, Ludwig A, Goldstein PA. 2011. PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons.. J Neurosci. 31(28):10412-23.

Malvezzi M, Andra KK, Pandey K, Lee B-C, Falzone ME, Brown A, Iqbal R, Menon AK, Accardi A. 2018. Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases.. Proc Natl Acad Sci U S A. 115(30):E7033-E7042.

Corral-Rodríguez MÁngeles, Stuiver M, Abascal-Palacios G, Diercks T, Oyenarte I, Ereño-Orbea J, de Opakua AIbáñez, Blanco FJ, Encinar JAntonio, Spiwok V et al.. 2014. Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.. Biochem J. 464(1):23-34.

Lee B-C, Menon AK, Accardi A. 2016. The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel.. Biophys J. 111(9):1919-1924.

Liantonio A, Accardi A, Carbonara G, Fracchiolla G, Loiodice F, Tortorella P, Traverso S, Guida P, Pierno S, De Luca A et al.. 2002. Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid.. Mol Pharmacol. 62(2):265-71.

Khelashvili G, Cheng X, Falzone ME, Doktorova M, Accardi A, Weinstein H. 2020. Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins.. J Comput Chem. 41(6):538-551.

Pusch M, Accardi A, Liantonio A, Guida P, Traverso S, Camerino DConte, Conti F. 2002. Mechanisms of block of muscle type CLC chloride channels (Review).. Mol Membr Biol. 19(4):285-92.

Falzone ME, Malvezzi M, Lee B-C, Accardi A. 2018. Known structures and unknown mechanisms of TMEM16 scramblases and channels.. J Gen Physiol.

Accardi A, Kolmakova-Partensky L, Williams C, Miller C. 2004. Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels.. J Gen Physiol. 123(2):109-19.

Jayaram H, Accardi A, Wu F, Williams C, Miller C. 2008. Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger.. Proc Natl Acad Sci U S A. 105(32):11194-9.

Lee B-C, Khelashvili G, Falzone M, Menon AK, Weinstein H, Accardi A. 2018. Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase.. Nat Commun. 9(1):3251.