Department of Anesthesiology
Author Title [ Type(Asc)] Year
Filters: Author is Accardi, Alessio  [Clear All Filters]
Journal Article
Accardi A.  2014.  Unveiling the secret lives of glutamate transporters: VGLUTs engage in multiple transport modes.. Neuron. 84(6):1110-2.
Walden M, Accardi A, Wu F, Xu C, Williams C, Miller C.  2007.  Uncoupling and turnover in a Cl-/H+ exchange transporter.. J Gen Physiol. 129(4):317-29.
Accardi A.  2008.  To ATP or not to ATP: this is the question.. J Gen Physiol. 131(2):105-8.
Picollo A, Malvezzi M, Accardi A.  2015.  TMEM16 proteins: unknown structure and confusing functions.. J Mol Biol. 427(1):94-105.
Picollo A, Xu Y, Johner N, Bernèche S, Accardi A.  2012.  Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H(+)/Cl(-) exchanger.. Nat Struct Mol Biol. 19(5):525-31,S1.
Accardi A, Lobet S, Williams C, Miller C, Dutzler R.  2006.  Synergism between halide binding and proton transport in a CLC-type exchanger.. J Mol Biol. 362(4):691-9.
Accardi A.  2015.  Structure and gating of CLC channels and exchangers.. J Physiol. 593(18):4129-38.
Chakraborty S, Feng Z, Lee S, Alvarenga OE, Panda A, Bruni R, Khelashvili G, Gupta K, Accardi A.  2024.  Structure and function of the human apoptotic scramblase Xkr4.. bioRxiv.
Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftici D, Falzone ME, Huysmans G, Robertson JL et al..  2024.  Structural basis of pH-dependent activation in a CLC transporter.. Nat Struct Mol Biol.
Feng Z, Alvarenga OE, Accardi A.  2024.  Structural basis of closed groove scrambling by a TMEM16 protein.. Nat Struct Mol Biol.
Accardi A, Walden M, Nguitragool W, Jayaram H, Williams C, Miller C.  2005.  Separate ion pathways in a Cl-/H+ exchanger.. J Gen Physiol. 126(6):563-70.
Accardi A, Miller C.  2004.  Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels.. Nature. 427(6977):803-7.
Fortea E, Accardi A.  2021.  A quantitative flux assay for the study of reconstituted Cl- channels and transporters.. Methods Enzymol. 652:243-272.
Terashima H, Picollo A, Accardi A.  2013.  Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels.. Proc Natl Acad Sci U S A. 110(48):19354-9.
Picollo A, Malvezzi M, Accardi A.  2010.  Proton block of the CLC-5 Cl-/H+ exchanger.. J Gen Physiol. 135(6):653-9.
Basilio D, Accardi A.  2015.  A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters.. J Vis Exp. (98)
Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, H Larsson P et al..  2024.  Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.. Nature.
Vien M, Basilio D, Leisle L, Accardi A.  2017.  Probing the conformation of a conserved glutamic acid within the Cl(-) pathway of a CLC H(+)/Cl(-) exchanger.. J Gen Physiol. 149(4):523-529.
Ying S-W, Tibbs GR, Picollo A, Abbas SY, R Sanford L, Accardi A, Hofmann F, Ludwig A, Goldstein PA.  2011.  PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons.. J Neurosci. 31(28):10412-23.
Malvezzi M, Andra KK, Pandey K, Lee B-C, Falzone ME, Brown A, Iqbal R, Menon AK, Accardi A.  2018.  Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases.. Proc Natl Acad Sci U S A. 115(30):E7033-E7042.
Corral-Rodríguez MÁngeles, Stuiver M, Abascal-Palacios G, Diercks T, Oyenarte I, Ereño-Orbea J, de Opakua AIbáñez, Blanco FJ, Encinar JAntonio, Spiwok V et al..  2014.  Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.. Biochem J. 464(1):23-34.
Lee B-C, Menon AK, Accardi A.  2016.  The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel.. Biophys J. 111(9):1919-1924.
Liantonio A, Accardi A, Carbonara G, Fracchiolla G, Loiodice F, Tortorella P, Traverso S, Guida P, Pierno S, De Luca A et al..  2002.  Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid.. Mol Pharmacol. 62(2):265-71.
Khelashvili G, Cheng X, Falzone ME, Doktorova M, Accardi A, Weinstein H.  2020.  Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins.. J Comput Chem. 41(6):538-551.
Pusch M, Accardi A, Liantonio A, Guida P, Traverso S, Camerino DConte, Conti F.  2002.  Mechanisms of block of muscle type CLC chloride channels (Review).. Mol Membr Biol. 19(4):285-92.