Title | Unveiling the secret lives of glutamate transporters: VGLUTs engage in multiple transport modes. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Accardi A |
Journal | Neuron |
Volume | 84 |
Issue | 6 |
Pagination | 1110-2 |
Date Published | 2014 Dec 17 |
ISSN | 1097-4199 |
Keywords | Animals, Chlorides, Glutamic Acid, Neurotransmitter Agents, Potassium, Synaptic Vesicles, Vesicular Glutamate Transport Protein 1 |
Abstract | Accumulation of glutamate in synaptic vesicles is mediated by vesicular glutamate transporters called VGLUTs. In the current issue of Neuron, Preobraschenski et al. (2014) show that the VGLUTs, in addition to transporting glutamate, also provide the conductances necessary to maintain the appropriate voltage and pH inside these vesicles. |
DOI | 10.1016/j.neuron.2014.12.008 |
Alternate Journal | Neuron |
PubMed ID | 25521371 |