Department of Anesthesiology

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Unveiling the secret lives of glutamate transporters: VGLUTs engage in multiple transport modes.

TitleUnveiling the secret lives of glutamate transporters: VGLUTs engage in multiple transport modes.
Publication TypeJournal Article
Year of Publication2014
AuthorsAccardi A
JournalNeuron
Volume84
Issue6
Pagination1110-2
Date Published2014 Dec 17
ISSN1097-4199
KeywordsAnimals, Chlorides, Glutamic Acid, Neurotransmitter Agents, Potassium, Synaptic Vesicles, Vesicular Glutamate Transport Protein 1
Abstract

Accumulation of glutamate in synaptic vesicles is mediated by vesicular glutamate transporters called VGLUTs. In the current issue of Neuron, Preobraschenski et al. (2014) show that the VGLUTs, in addition to transporting glutamate, also provide the conductances necessary to maintain the appropriate voltage and pH inside these vesicles.

DOI10.1016/j.neuron.2014.12.008
Alternate JournalNeuron
PubMed ID25521371