Department of Anesthesiology
Author Title [ Type(Asc)] Year
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Journal Article
Schmidpeter PAM, Gao X, Uphadyay V, Rheinberger J, Nimigean CM.  2018.  Ligand binding and activation properties of the purified bacterial cyclic nucleotide-gated channel SthK.. J Gen Physiol.
Nimigean CM, Pagel MD.  2007.  Ligand binding and activation in a prokaryotic cyclic nucleotide-modulated channel.. J Mol Biol. 371(5):1325-37.
McCoy JG, Rusinova R, Kim DM, Kowal J, Banerjee S, Cartagena AJaramillo, Thompson AN, Kolmakova-Partensky L, Stahlberg H, Andersen OS et al..  2014.  A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics.. J Biol Chem. 289(14):9535-46.
Xu Y, Zhang D, Rogawski R, Nimigean CM, McDermott AE.  2019.  Identifying coupled clusters of allostery participants through chemical shift perturbations.. Proc Natl Acad Sci U S A. 116(6):2078-2085.
Menny A, Lefebvre SN, Schmidpeter PAm, Drège E, Fourati Z, Delarue M, Edelstein SJ, Nimigean CM, Joseph D, Corringer P-J.  2017.  Identification of a pre-active conformation of a pentameric channel receptor.. Elife. 6
Kowal J, Biyani N, Chami M, Scherer S, Rzepiela AJ, Baumgartner P, Upadhyay V, Nimigean CM, Stahlberg H.  2018.  High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer.. Structure. 26(1):20-27.e3.
Gao X, Schmidpeter PAM, Berka V, Durham RJ, Fan C, Jayaraman V, Nimigean CM.  2022.  Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.. Nat Commun. 13(1):6919.
Nimigean CM, Chappie JS, Miller C.  2003.  Electrostatic tuning of ion conductance in potassium channels.. Biochemistry. 42(31):9263-8.
Pan Y, Pohjolainen E, Schmidpeter PAM, Vaiana AC, Nimigean CM, Grubmüller H, Scheuring S.  2023.  Discrimination between cyclic nucleotides in a cyclic nucleotide-gated ion channel.. Nat Struct Mol Biol. 30(4):512-520.
Nimigean CM, Shane T, Miller C.  2004.  A cyclic nucleotide modulated prokaryotic K+ channel.. J Gen Physiol. 124(3):203-10.
Schmidpeter PAM, Nimigean CM.  2021.  Correlating ion channel structure and function.. Methods Enzymol. 652:3-30.
Kim DM, Dikiy I, Upadhyay V, Posson DJ, Eliezer D, Nimigean CM.  2016.  Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles.. J Gen Physiol. 148(2):119-32.
Fan C, Flood E, Sukomon N, Agarwal S, Allen TW, Nimigean CM.  2023.  Calcium-gated potassium channel blockade via membrane-facing fenestrations.. Nat Chem Biol.
Zadek B, Nimigean CM.  2006.  Calcium-dependent gating of MthK, a prokaryotic potassium channel.. J Gen Physiol. 127(6):673-85.
Posson DJ, Rusinova R, Andersen OS, Nimigean CM.  2015.  Calcium ions open a selectivity filter gate during activation of the MthK potassium channel.. Nat Commun. 6:8342.
Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM.  2025.  Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel.. Nat Commun. 16(1):1769.
Sukomon N, Fan C, Nimigean CM.  2022.  Ball-and-Chain Inactivation in Potassium Channels.. Annu Rev Biophys.
Fan C, Sukomon N, Flood E, Rheinberger J, Allen TW, Nimigean CM.  2020.  Ball-and-chain inactivation in a calcium-gated potassium channel.. Nature. 580(7802):288-293.
Schmidpeter PAM, Wu D, Rheinberger J, Riegelhaupt PM, Tang H, Robinson CV, Nimigean CM.  2022.  Anionic lipids unlock the gates of select ion channels in the pacemaker family.. Nat Struct Mol Biol. 29(11):1092-1100.
Nimigean CM.  2022.  35 years of channelling potassium ions.. Nature. 608(7924):670-672.