Department of Anesthesiology
Author Title [ Type(Asc)] Year
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Journal Article
Tibbs GR, Posson DJ, Goldstein PA.  2016.  Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain? Trends Pharmacol Sci. 37(7):522-42.
Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, H Larsson P et al..  2024.  Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.. Nature.
Joyce RL, Tibbs GR, J Warren D, Costa CJ, Aromolaran K, R Sanford L, Andersen OS, Li Z, Zhang G, Willis DE et al..  2023.  Probucol is anti-hyperalgesic in a mouse peripheral nerve injury model of neuropathic pain.. Neurobiol Pain. 14:100141.
Ying S-W, Tibbs GR, Picollo A, Abbas SY, R Sanford L, Accardi A, Hofmann F, Ludwig A, Goldstein PA.  2011.  PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons.. J Neurosci. 31(28):10412-23.
Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA.  2005.  Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol.. J Pharmacol Exp Ther. 315(2):517-25.
Tibbs GR, Rowley TJ, R Sanford L, Herold KF, Proekt A, Hemmings HC, Andersen OS, Goldstein PA, Flood PD.  2013.  HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.. J Pharmacol Exp Ther. 345(3):363-73.
Riegelhaupt PM, Tibbs GR, Goldstein PA.  2018.  HCN and K Channels in Anesthetic Mechanisms Research.. Methods Enzymol. 602:391-416.
Lyashchenko AK, Redd KJ, Goldstein PA, Tibbs GR.  2014.  cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.. PLoS One. 9(7):e101236.
Tibbs GR, Uprety R, J Warren D, Beyer NP, Joyce RL, Ferrer MA, Mellado W, Wong VSC, Goldberg DC, Cohen MW et al..  2023.  An anchor-tether 'hindered' HCN1 inhibitor is antihyperalgesic in a rat spared nerve injury neuropathic pain model.. Br J Anaesth.
Joyce RL, Beyer NP, Vasilopoulos G, Woll K, Hall AC, Eckenhoff RG, Barman DN, J Warren D, Tibbs GR, Goldstein PA.  2019.  Alkylphenol inverse agonists of HCN1 gating: H-bond propensity, ring saturation and adduct geometry differentially determine efficacy and potency.. Biochem Pharmacol.