Department of Anesthesiology
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Journal Article
Levin EJ, Elsen NL, Seder KD, McCoy JG, Fox BG, Phillips GN.  2008.  X-ray structure of a soluble Rieske-type ferredoxin from Mus musculus.. Acta Crystallogr D Biol Crystallogr. 64(Pt 9):933-40.
Zhu J, Choi W-S, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D et al..  2012.  Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS.. Sci Transl Med. 4(125):125ra32.
Bitto E, Bingman CA, Wesenberg GE, McCoy JG, Phillips GN.  2006.  Structure of pyrimidine 5'-nucleotidase type 1. Insight into mechanism of action and inhibition during lead poisoning.. J Biol Chem. 281(29):20521-9.
McCoy JG, Bingman CA, Bitto E, Holdorf MM, Makaroff CA, Phillips GN.  2006.  Structure of an ETHE1-like protein from Arabidopsis thaliana.. Acta Crystallogr D Biol Crystallogr. 62(Pt 9):964-70.
Bitto E, Bingman CA, McCoy JG, Allard STM, Wesenberg GE, Phillips GN.  2005.  The structure at 1.6 Angstroms resolution of the protein product of the At4g34215 gene from Arabidopsis thaliana.. Acta Crystallogr D Biol Crystallogr. 61(Pt 12):1655-61.
McCoy JG, Bailey LJ, Bitto E, Bingman CA, Aceti DJ, Fox BG, Phillips GN.  2006.  Structure and mechanism of mouse cysteine dioxygenase.. Proc Natl Acad Sci U S A. 103(9):3084-9.
McCoy JG, Arabshahi A, Bitto E, Bingman CA, Ruzicka FJ, Frey PA, Phillips GN.  2006.  Structure and mechanism of an ADP-glucose phosphorylase from Arabidopsis thaliana.. Biochemistry. 45(10):3154-62.
McCoy JG, Bitto E, Bingman CA, Wesenberg GE, Bannen RM, Kondrashov DA, Phillips GN.  2007.  Structure and dynamics of UDP-glucose pyrophosphorylase from Arabidopsis thaliana with bound UDP-glucose and UTP.. J Mol Biol. 366(3):830-41.
Liantonio A, De Luca A, Pierno S, Didonna MPaola, Loiodice F, Fracchiolla G, Tortorella P, Antonio L, Bonerba E, Traverso S et al..  2003.  Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1.. Br J Pharmacol. 139(7):1255-64.
Gradogna A, Babini E, Picollo A, Pusch M.  2010.  A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.. J Gen Physiol. 136(3):311-23.
Picollo A, Malvezzi M, Accardi A.  2010.  Proton block of the CLC-5 Cl-/H+ exchanger.. J Gen Physiol. 135(6):653-9.
Thon O, Wang Z, Schmidpeter PAM, Nimigean CM.  2024.  PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK.. Nat Commun. 15(1):8230.
Porotto M, Fornabaio M, Greengard O, Murrell MT, Kellogg GE, Moscona A.  2006.  Paramyxovirus receptor-binding molecules: engagement of one site on the hemagglutinin-neuraminidase protein modulates activity at the second site.. J Virol. 80(3):1204-13.
Jovanovic JN, Sihra TS, Nairn AC, Hemmings HC, Greengard P, Czernik AJ.  2001.  Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals.. J Neurosci. 21(20):7944-53.
Corral-Rodríguez MÁngeles, Stuiver M, Abascal-Palacios G, Diercks T, Oyenarte I, Ereño-Orbea J, de Opakua AIbáñez, Blanco FJ, Encinar JAntonio, Spiwok V et al..  2014.  Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.. Biochem J. 464(1):23-34.
Hemmings HC.  2007.  Noble meets nouveau: a shared anesthetic binding site for xenon and isoflurane on a glutamate receptor.. Anesthesiology. 107(5):694-6.
Picollo A, Liantonio A, Didonna MPaola, Elia L, Camerino DConte, Pusch M.  2004.  Molecular determinants of differential pore blocking of kidney CLC-K chloride channels.. EMBO Rep. 5(6):584-9.
Naguib M, Gottumukkala V, Goldstein PA.  2007.  Melatonin and anesthesia: a clinical perspective.. J Pineal Res. 42(1):12-21.
Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia BA, Nimigean CM, Eckenhoff RG, Riegelhaupt PM.  2020.  Mechanistic insights into volatile anesthetic modulation of K2P channels.. Elife. 9
Thompson AN, Kim I, Panosian TD, Iverson TM, Allen TW, Nimigean CM.  2009.  Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore.. Nat Struct Mol Biol. 16(12):1317-24.
Zifarelli G, Liantonio A, Gradogna A, Picollo A, Gramegna G, De Bellis M, Murgia AR, Babini E, D Camerino C, Pusch M.  2010.  Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels.. Br J Pharmacol. 160(7):1652-61.
Estévez R, Schroeder BC, Accardi A, Jentsch TJ, Pusch M.  2003.  Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1.. Neuron. 38(1):47-59.
Accardi A, Pusch M.  2003.  Conformational changes in the pore of CLC-0.. J Gen Physiol. 122(3):277-93.
Sokolova O, Accardi A, Gutierrez D, Lau A, Rigney M, Grigorieff N.  2003.  Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit.. Proc Natl Acad Sci U S A. 100(22):12607-12.
Accardi A, Picollo A.  2010.  CLC channels and transporters: proteins with borderline personalities.. Biochim Biophys Acta. 1798(8):1457-64.