The comparative effects of sevoflurane versus propofol in the induction and maintenance of anesthesia in adult patients.

TitleThe comparative effects of sevoflurane versus propofol in the induction and maintenance of anesthesia in adult patients.
Publication TypeJournal Article
Year of Publication1996
AuthorsJellish WS, Lien CA, Fontenot HJ, Hall R
JournalAnesth Analg
Date Published1996 Mar
KeywordsAdult, Analgesia, Anesthesia Recovery Period, Anesthesia, Inhalation, Anesthesia, Intravenous, Anesthetics, Inhalation, Anesthetics, Intravenous, Creatinine, Ethers, Female, Humans, Hydrogen-Ion Concentration, Intubation, Intratracheal, Male, Methyl Ethers, Nausea, Nitrous Oxide, Orientation, Pain, Postoperative, Postoperative Complications, Propofol, Prospective Studies, Respiration, Specific Gravity, Urine, Vomiting

A randomized, prospective study was performed at four institutions to compare anesthetic induction, maintenance, and recovery characteristics between sevoflurane- and propofol-based anesthesia in 186 ASA physical status I and 11 patients undergoing elective surgical procedures of 1-3 h. Group 1 (n = 93) patients received sevoflurane-nitrous oxide for both induction and maintenance of anesthesia while Group 2 (n = 93) received propofol-nitrous oxide anesthesia. Induction of anesthesia and tracheal intubation times were significantly shorter with propofol (2.21 +/- 0.2 min, 5.11 +/- 0.3 min, respectively) than with sevoflurane (3.11 +/- 0.2 min, 7.21 +/- 0.3 min, respectively). Emergence times after sevoflurane (8.81 +/- 1.2 min) were significantly shorter than with propofol (13.21 +/- 1.2 min). Overall frequency of complication-free induction, maintenance, and emergence did not differ between the two anesthetic groups. However, side effects involving airway excitement were more prevalent during mask induction with sevoflurane as compared to propofol. Patients in the sevoflurane group were oriented and required postoperative analgesia much earlier than those who received propofol. Both groups were hemodynamically stable throughout the study period. The incidence of postoperative nausea, vomiting, and pain-discomfort scores were similar between the two groups. Urinary specific gravity decreased in the sevoflurane-treated group while serum creatinine and urinary pH were unchanged from preoperative values in both groups. Sevoflurane compared favorably with propofol when used for anesthesia for elective procedures of 1-3 h duration.

Alternate JournalAnesth. Analg.
PubMed ID8623947