Department of Anesthesiology
Author Title Type [ Year(Asc)]
Filters: Keyword is Anesthetics, Inhalation  [Clear All Filters]
2025
Riel EB, Bu W, Joseph TT, Khajoueinejad L, Eckenhoff RG, Riegelhaupt PM.  2025.  The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel.. Proc Natl Acad Sci U S A. 122(14):e2421654122.
2021
Speigel IA, Hemmings HC.  2021.  Selective inhibition of gamma aminobutyric acid release from mouse hippocampal interneurone subtypes by the volatile anaesthetic isoflurane.. Br J Anaesth. 127(4):587-599.
2020
Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia BA, Nimigean CM, Eckenhoff RG, Riegelhaupt PM.  2020.  Mechanistic insights into volatile anesthetic modulation of K2P channels.. Elife. 9
2015
Purtell K, Gingrich KJ, OuYang W, Herold KF, Hemmings HC.  2015.  Activity-dependent depression of neuronal sodium channels by the general anaesthetic isoflurane.. Br J Anaesth. 115(1):112-21.
Mattusch C, Kratzer S, Buerge M, Kreuzer M, Engel T, Kopp C, Biel M, Hammelmann V, Ying S-W, Goldstein PA et al..  2015.  Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments.. Anesthesiology. 122(5):1047-59.
2014
Platholi J, Herold KF, Hemmings HC, Halpain S.  2014.  Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism.. PLoS One. 9(7):e102978.
Herold KF, R Sanford L, Lee W, Schultz MF, Ingólfsson HI, Andersen OS, Hemmings HC.  2014.  Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties.. J Gen Physiol. 144(6):545-60.
2013
Westphalen RI, Desai KM, Hemmings HC.  2013.  Presynaptic inhibition of the release of multiple major central nervous system neurotransmitter types by the inhaled anaesthetic isoflurane.. Br J Anaesth. 110(4):592-9.
2010
Zhang Y, Guzinski M, Eger EI, Laster MJ, Sharma M, Harris RA, Hemmings HC.  2010.  Bidirectional modulation of isoflurane potency by intrathecal tetrodotoxin and veratridine in rats.. Br J Pharmacol. 159(4):872-8.
2009
Perouansky M, Hemmings HC.  2009.  Between Clotho and Lachesis: how isoflurane seals neuronal fate.. Anesthesiology. 110(4):709-11.
Ouyang W, Herold KF, Hemmings HC.  2009.  Comparative effects of halogenated inhaled anesthetics on voltage-gated Na+ channel function.. Anesthesiology. 110(3):582-90.
Herold KF, Nau C, Ouyang W, Hemmings HC.  2009.  Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8.. Anesthesiology. 111(3):591-9.
Ying S-W, Werner DF, Homanics GE, Harrison NL, Goldstein PA.  2009.  Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms.. Neuropharmacology. 56(2):438-47.
Westphalen RI, Gomez RS, Hemmings HC.  2009.  Nicotinic receptor-evoked hippocampal norepinephrine release is highly sensitive to inhibition by isoflurane.. Br J Anaesth. 102(3):355-60.
Hemmings HC.  2009.  Sodium channels and the synaptic mechanisms of inhaled anaesthetics.. Br J Anaesth. 103(1):61-9.
2008
Hemmings HC, Flood P.  2008.  Galloping in full pursuit of the mechanism of anesthetic immobility.. Anesthesiology. 108(6):975-6.
Eger EI, Raines DE, Shafer SL, Hemmings HC, Sonner JM.  2008.  Is a new paradigm needed to explain how inhaled anesthetics produce immobility? Anesth Analg. 107(3):832-48.
Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA, Christini DJ, Peters NS, Akar FG et al..  2008.  Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f).. FASEB J. 22(10):3648-60.
2007
Snyder GL, Galdi S, Hendrick JP, Hemmings HC.  2007.  General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo.. Neuropharmacology. 53(5):619-30.
Ouyang W, Jih T-Y, Zhang T-T, Correa AM, Hemmings HC.  2007.  Isoflurane inhibits NaChBac, a prokaryotic voltage-gated sodium channel.. J Pharmacol Exp Ther. 322(3):1076-83.
Ouyang W, Hemmings HC.  2007.  Isoform-selective effects of isoflurane on voltage-gated Na+ channels.. Anesthesiology. 107(1):91-8.
Hemmings HC.  2007.  Noble meets nouveau: a shared anesthetic binding site for xenon and isoflurane on a glutamate receptor.. Anesthesiology. 107(5):694-6.
Westphalen RI, Krivitski M, Amarosa A, Guy N, Hemmings HC.  2007.  Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1.. Br J Pharmacol. 152(6):939-45.
2006
Westphalen RI, Hemmings HC.  2006.  Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: 4-aminopyridine-evoked release.. J Pharmacol Exp Ther. 316(1):216-23.
Westphalen RI, Hemmings HC.  2006.  Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: basal release.. J Pharmacol Exp Ther. 316(1):208-15.