Department of Anesthesiology

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Publications

Author Title [ Type(Desc)] Year
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Journal Article
Picollo A, Malvezzi M, Houtman JCD, Accardi A.  2009.  Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters.. Nat Struct Mol Biol. 16(12):1294-301.
Iyer R, Iverson TM, Accardi A, Miller C.  2002.  A biological role for prokaryotic ClC chloride channels.. Nature. 419(6908):715-8.
Malvezzi M, Chalat M, Janjusevic R, Picollo A, Terashima H, Menon AK, Accardi A.  2013.  Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel.. Nat Commun. 4:2367.
Accardi A.  2015.  CELL SIGNALING. Lipids link ion channels and cancer.. Science. 349(6250):789-90.
Accardi A, Picollo A.  2010.  CLC channels and transporters: proteins with borderline personalities.. Biochim Biophys Acta. 1798(8):1457-64.
Sokolova O, Accardi A, Gutierrez D, Lau A, Rigney M, Grigorieff N.  2003.  Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit.. Proc Natl Acad Sci U S A. 100(22):12607-12.
Accardi A, Pusch M.  2003.  Conformational changes in the pore of CLC-0.. J Gen Physiol. 122(3):277-93.
Basilio D, Noack K, Picollo A, Accardi A.  2014.  Conformational changes required for H(+)/Cl(-) exchange mediated by a CLC transporter.. Nat Struct Mol Biol. 21(5):456-63.
Estévez R, Schroeder BC, Accardi A, Jentsch TJ, Pusch M.  2003.  Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1.. Neuron. 38(1):47-59.
Khelashvili G, Falzone ME, Cheng X, Lee B-C, Accardi A, Weinstein H.  2019.  Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca-bound nhTMEM16.. Nat Commun. 10(1):4972.
Hara Y, Balci-Hayta B, Yoshida-Moriguchi T, Kanagawa M, de Bernabé DBeltrán-V, Gündeşli H, Willer T, Satz JS, Crawford RW, Burden SJ et al..  2011.  A dystroglycan mutation associated with limb-girdle muscular dystrophy.. N Engl J Med. 364(10):939-46.
Lee B-C, Khelashvili G, Falzone M, Menon AK, Weinstein H, Accardi A.  2018.  Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase.. Nat Commun. 9(1):3251.
Jayaram H, Accardi A, Wu F, Williams C, Miller C.  2008.  Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger.. Proc Natl Acad Sci U S A. 105(32):11194-9.
Accardi A, Kolmakova-Partensky L, Williams C, Miller C.  2004.  Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels.. J Gen Physiol. 123(2):109-19.
Falzone ME, Malvezzi M, Lee B-C, Accardi A.  2018.  Known structures and unknown mechanisms of TMEM16 scramblases and channels.. J Gen Physiol.
Pusch M, Accardi A, Liantonio A, Guida P, Traverso S, Camerino DConte, Conti F.  2002.  Mechanisms of block of muscle type CLC chloride channels (Review).. Mol Membr Biol. 19(4):285-92.
Liantonio A, Accardi A, Carbonara G, Fracchiolla G, Loiodice F, Tortorella P, Traverso S, Guida P, Pierno S, De Luca A et al..  2002.  Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid.. Mol Pharmacol. 62(2):265-71.
Lee B-C, Menon AK, Accardi A.  2016.  The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel.. Biophys J. 111(9):1919-1924.
Corral-Rodríguez MÁngeles, Stuiver M, Abascal-Palacios G, Diercks T, Oyenarte I, Ereño-Orbea J, de Opakua AIbáñez, Blanco FJ, Encinar JAntonio, Spiwok V et al..  2014.  Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.. Biochem J. 464(1):23-34.
Malvezzi M, Andra KK, Pandey K, Lee B-C, Falzone ME, Brown A, Iqbal R, Menon AK, Accardi A.  2018.  Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases.. Proc Natl Acad Sci U S A. 115(30):E7033-E7042.
Ying S-W, Tibbs GR, Picollo A, Abbas SY, R Sanford L, Accardi A, Hofmann F, Ludwig A, Goldstein PA.  2011.  PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons.. J Neurosci. 31(28):10412-23.
Vien M, Basilio D, Leisle L, Accardi A.  2017.  Probing the conformation of a conserved glutamic acid within the Cl(-) pathway of a CLC H(+)/Cl(-) exchanger.. J Gen Physiol. 149(4):523-529.
Basilio D, Accardi A.  2015.  A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters.. J Vis Exp. (98)
Picollo A, Malvezzi M, Accardi A.  2010.  Proton block of the CLC-5 Cl-/H+ exchanger.. J Gen Physiol. 135(6):653-9.
Terashima H, Picollo A, Accardi A.  2013.  Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels.. Proc Natl Acad Sci U S A. 110(48):19354-9.