Department of Anesthesiology

You are here

The future of the benzylisoquinolinium relaxants.

TitleThe future of the benzylisoquinolinium relaxants.
Publication TypeJournal Article
Year of Publication1995
AuthorsSavarese JJ, Wastila WB
JournalActa Anaesthesiol Scand Suppl
Volume106
Pagination91-3
Date Published1995
ISSN0515-2720
KeywordsAnesthesia Recovery Period, Atracurium, Drug Design, Drug Hypersensitivity, Forecasting, Half-Life, Histamine Release, Humans, Isomerism, Isoquinolines, Neuromuscular Nondepolarizing Agents
Abstract

The benzylisoquinolinium relaxants currently include the intermediate-acting agent, atracurium, and the short-acting agent, mivacurium. This class of relaxants has always retained the distinct advantages of rapid degradation, enzymatic metabolism, or both in the plasma, resulting in short half-lives and fast, complete recovery, unrelated to dose or duration of administration. Any improvements in this class of relaxants must focus on retaining this property at the same time as decreasing or eliminating histamine release, which has always been the major disadvantage of the benzylisoquinoliniums. The introduction of 51W89, an isomer of atracurium, may represent an advance in the development of this class of relaxants.

Alternate JournalActa Anaesthesiol Scand Suppl
PubMed ID8533554