Department of Anesthesiology
Author Title Type [ Year(Asc)]
Filters: Keyword is Isoquinolines  [Clear All Filters]
2015
Martin-Flores M, Cheetham J, Campoy L, Sakai DM, Heerdt PM, Gleed RD.  2015.  Effect of gantacurium on evoked laryngospasm and duration of apnea in anesthetized healthy cats.. Am J Vet Res. 76(3):216-23.
2014
Diaz LL, Zhang J, Heerdt PM.  2014.  Comparative pharmacodynamics of pancuronium, cisatracurium, and CW002 in rabbits.. J Am Assoc Lab Anim Sci. 53(3):283-9.
2011
Lien CA.  2011.  Development and potential clinical impairment of ultra-short-acting neuromuscular blocking agents.. Br J Anaesth. 107 Suppl 1:i60-71.
2010
Sunaga H, Malhotra JK, Yoon E, Savarese JJ, Heerdt PM.  2010.  Cysteine reversal of the novel neuromuscular blocking drug CW002 in dogs: pharmacodynamics, acute cardiovascular effects, and preliminary toxicology.. Anesthesiology. 112(4):900-9.
Sunaga H, Zhang Y, Savarese JJ, Emala CW.  2010.  Gantacurium and CW002 do not potentiate muscarinic receptor-mediated airway smooth muscle constriction in guinea pigs.. Anesthesiology. 112(4):892-9.
Heerdt PM, Malhotra JK, Pan BY, Sunaga H, Savarese JJ.  2010.  Pharmacodynamics and cardiopulmonary side effects of CW002, a cysteine-reversible neuromuscular blocking drug in dogs.. Anesthesiology. 112(4):910-6.
Savarese JJ, McGilvra JD, Sunaga H, Belmont MR, Van Ornum SG, Savard PM, Heerdt PM.  2010.  Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011.. Anesthesiology. 113(1):58-73.
2009
Lien CA, Savard P, Belmont M, Sunaga H, Savarese JJ.  2009.  Fumarates: unique nondepolarizing neuromuscular blocking agents that are antagonized by cysteine.. J Crit Care. 24(1):50-7.
2005
Lien CA, Belmont MR, Heerdt PM.  2005.  GW280430A: pharmacodynamics and potential adverse effects.. Anesthesiology. 102(4):861-2;authorreply862-3.
2004
Heerdt PM, Kang R, The' A, Hashim M, Mook RJ, Savarese JJ.  2004.  Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs.. Anesthesiology. 100(4):846-51.
Belmont MR, Lien CA, Tjan J, Bradley E, Stein B, Patel SS, Savarese JJ.  2004.  Clinical pharmacology of GW280430A in humans.. Anesthesiology. 100(4):768-73.
Savarese JJ, Belmont MR, Hashim MA, Mook RA, Boros EE, Samano V, Patel SS, Feldman PL, Schultz J-AI, McNulty M et al..  2004.  Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: a comparison with mivacurium.. Anesthesiology. 100(4):835-45.
2003
Suzuki T, Lien CA, Belmont MR, Tjan J, Savarese JJ.  2003.  Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium.. Can J Anaesth. 50(9):879-85.
Boros EE, Samano V, Ray JA, Thompson JB, Jung DK, Kaldor I, Koble CS, Martin MT, Styles VL, Mook RA et al..  2003.  Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys.. J Med Chem. 46(12):2502-15.
1999
Lien CA, Belmont MR, Abalos A, Hass D, Savarese JJ.  1999.  The nature of spontaneous recovery from mivacurium-induced neuromuscular block.. Anesth Analg. 88(3):648-53.
Lien CA, Belmont MR, Roth DLWray, Okamoto M, Abalos A, Savarese JJ.  1999.  Pharmacodynamics and the plasma concentration of mivacurium during spontaneous recovery and neostigmine-facilitated recovery.. Anesthesiology. 91(1):119-26.
1997
Savarese JJ, Lien CA, Belmont MR, Wastila WB.  1997.  [The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and mivacurium].. Anaesthesist. 46(10):840-9.
1996
Savarese JJ, Lien CA, Belmont MR.  1996.  Antagonism of residual mivacurium blockade: setting the record straight.. Anesthesiology. 84(6):1525-8.
Kisor DF, Schmith VD, Wargin WA, Lien CA, Ornstein E, Cook DR.  1996.  Importance of the organ-independent elimination of cisatracurium.. Anesth Analg. 83(5):1065-71.
Lien CA, Schmith VD, Belmont MR, Abalos A, Kisor DF, Savarese JJ.  1996.  Pharmacokinetics of cisatracurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia.. Anesthesiology. 84(2):300-8.
1995
Savarese JJ, Lien CA, Belmont MR.  1995.  The accuracy of the 5%-25% (T1-T3) twitch recovery interval in predicting the speed of spontaneous recovery from mivacurium-induced neuromuscular blockade.. Anesth Analg. 80(1):209-10.
Savarese JJ, Lien CA, Belmont MR, Rubin L.  1995.  The clinical and basic pharmacology of mivacurium: a short-acting nondepolarizing benzylisoquinolinium diester neuromuscular blocking drug.. Acta Anaesthesiol Scand Suppl. 106:18-22.
Savarese JJ, Wastila WB.  1995.  The future of the benzylisoquinolinium relaxants.. Acta Anaesthesiol Scand Suppl. 106:91-3.
1994
Lien CA, Schmith VD, Embree PB, Belmont MR, Wargin WA, Savarese JJ.  1994.  The pharmacokinetics and pharmacodynamics of the stereoisomers of mivacurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia.. Anesthesiology. 80(6):1296-302.
1990
Dresner DL, Basta SJ, Ali HH, Schwartz AF, Embree PB, Wargin WA, Lai AA, Brady KA, Savarese JJ.  1990.  Pharmacokinetics and pharmacodynamics of doxacurium in young and elderly patients during isoflurane anesthesia.. Anesth Analg. 71(5):498-502.