Department of Anesthesiology

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The clinical and basic pharmacology of mivacurium: a short-acting nondepolarizing benzylisoquinolinium diester neuromuscular blocking drug.

TitleThe clinical and basic pharmacology of mivacurium: a short-acting nondepolarizing benzylisoquinolinium diester neuromuscular blocking drug.
Publication TypeJournal Article
Year of Publication1995
AuthorsSavarese JJ, Lien CA, Belmont MR, Rubin L
JournalActa Anaesthesiol Scand Suppl
Volume106
Pagination18-22
Date Published1995
ISSN0515-2720
KeywordsCholinesterases, Drug Design, Drug Industry, Half-Life, Hospitals, General, Humans, Hydrolysis, Isoquinolines, Neuromuscular Nondepolarizing Agents, Succinylcholine
Abstract

Mivacurium is a benzylisoquinolinium diester. The drug is a nondepolarizing relaxant which is hydrolysed by plasma cholinesterase at 70-88% of the rate of suxamethonium. Enzymatic hydrolysis gives the drug its short duration of action. The length of paralysis is about 2-2.5 times that of suxamethonium and one-half to one-third that of the intermediate-acting nondepolarizers. The development of mivacurium represents a collaboration between industrial pharmacologists and chemists at Burroughs Wellcome Co. (USA) and investigators at the Massachusetts General Hospital, Boston, MA, USA.

Alternate JournalActa Anaesthesiol Scand Suppl
PubMed ID8533538