| Title | The clinical and basic pharmacology of mivacurium: a short-acting nondepolarizing benzylisoquinolinium diester neuromuscular blocking drug. |
| Publication Type | Journal Article |
| Year of Publication | 1995 |
| Authors | Savarese JJ, Lien CA, Belmont MR, Rubin L |
| Journal | Acta Anaesthesiol Scand Suppl |
| Volume | 106 |
| Pagination | 18-22 |
| Date Published | 1995 |
| ISSN | 0515-2720 |
| Keywords | Cholinesterases, Drug Design, Drug Industry, Half-Life, Hospitals, General, Humans, Hydrolysis, Isoquinolines, Neuromuscular Nondepolarizing Agents, Succinylcholine |
| Abstract | Mivacurium is a benzylisoquinolinium diester. The drug is a nondepolarizing relaxant which is hydrolysed by plasma cholinesterase at 70-88% of the rate of suxamethonium. Enzymatic hydrolysis gives the drug its short duration of action. The length of paralysis is about 2-2.5 times that of suxamethonium and one-half to one-third that of the intermediate-acting nondepolarizers. The development of mivacurium represents a collaboration between industrial pharmacologists and chemists at Burroughs Wellcome Co. (USA) and investigators at the Massachusetts General Hospital, Boston, MA, USA. |
| Alternate Journal | Acta Anaesthesiol Scand Suppl |
| PubMed ID | 8533538 |