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Robust alternative to the righting reflex to assess arousal in rodents.

TitleRobust alternative to the righting reflex to assess arousal in rodents.
Publication TypeJournal Article
Year of Publication2020
AuthorsGao S, Calderon DPaola
JournalSci Rep
Volume10
Issue1
Pagination20280
Date Published2020 Nov 20
ISSN2045-2322
Abstract

The righting reflex (RR) is frequently used to assess level of arousal and applied to animal models of a range of neurological disorders. RR produces a binary result that, when positive, is used to infer restoration of consciousness, often without further behavioral corroboration. We find that RR is an unreliable metric for arousal/recovery of consciousness. Instead, cortical activity and motor behavior that accompany RR are a non-binary, superior criterion that accurately calibrates and establishes level of arousal in rodents.

DOI10.1038/s41598-020-77162-3
Alternate JournalSci Rep
PubMed ID33219247
PubMed Central IDPMC7679463
Grant ListR01 NS094655 / NS / NINDS NIH HHS / United States
NS094655 / NS / NINDS NIH HHS / United States