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Department of Anesthesiology

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Re-evaluation of dosage and duration of action of d-tubocurarine in the pediatric age group.

TitleRe-evaluation of dosage and duration of action of d-tubocurarine in the pediatric age group.
Publication TypeJournal Article
Year of Publication1975
AuthorsGoudsouzian NG, Donlon JV, Savarese JJ, Ryan JF
Date Published1975 Oct
KeywordsAge Factors, Body Weight, Child, Child, Preschool, Dose-Response Relationship, Drug, Halothane, Humans, Infant, Infant, Newborn, Neuromuscular Junction, Nitrous Oxide, Synaptic Transmission, Time Factors, Tubocurarine

A cumulative dose-response curve for d-tubocurarine based on body weight was determined for 44 infants and children 1 day to 7 years of age during halothane, nitrous oxide and oxygen anesthesia. Depression of thumb adduction was measured. Age difference did not affect the mean dose-effect response. Infants less than 10 days old, however, showed the wideest deviation of responses. When the effect of d-tubocurarine is determined by twitch response, infants and children are more resistant to d-tubocurarine and recover faster than adults from similar levels of neuromuscular depression. Monitoring of neuromuscular function by train-of-four stimulation proved as useful as it is in adults.

Alternate JournalAnesthesiology
PubMed ID170845