Department of Anesthesiology

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Re-evaluation of dosage and duration of action of d-tubocurarine in the pediatric age group.

TitleRe-evaluation of dosage and duration of action of d-tubocurarine in the pediatric age group.
Publication TypeJournal Article
Year of Publication1975
AuthorsGoudsouzian NG, Donlon JV, Savarese JJ, Ryan JF
JournalAnesthesiology
Volume43
Issue4
Pagination416-25
Date Published1975 Oct
ISSN0003-3022
KeywordsAge Factors, Body Weight, Child, Child, Preschool, Dose-Response Relationship, Drug, Halothane, Humans, Infant, Infant, Newborn, Neuromuscular Junction, Nitrous Oxide, Synaptic Transmission, Time Factors, Tubocurarine
Abstract

A cumulative dose-response curve for d-tubocurarine based on body weight was determined for 44 infants and children 1 day to 7 years of age during halothane, nitrous oxide and oxygen anesthesia. Depression of thumb adduction was measured. Age difference did not affect the mean dose-effect response. Infants less than 10 days old, however, showed the wideest deviation of responses. When the effect of d-tubocurarine is determined by twitch response, infants and children are more resistant to d-tubocurarine and recover faster than adults from similar levels of neuromuscular depression. Monitoring of neuromuscular function by train-of-four stimulation proved as useful as it is in adults.

Alternate JournalAnesthesiology
PubMed ID170845