| Title | Re-evaluation of dosage and duration of action of d-tubocurarine in the pediatric age group. |
| Publication Type | Journal Article |
| Year of Publication | 1975 |
| Authors | Goudsouzian NG, Donlon JV, Savarese JJ, Ryan JF |
| Journal | Anesthesiology |
| Volume | 43 |
| Issue | 4 |
| Pagination | 416-25 |
| Date Published | 1975 Oct |
| ISSN | 0003-3022 |
| Keywords | Age Factors, Body Weight, Child, Child, Preschool, Dose-Response Relationship, Drug, Halothane, Humans, Infant, Infant, Newborn, Neuromuscular Junction, Nitrous Oxide, Synaptic Transmission, Time Factors, Tubocurarine |
| Abstract | A cumulative dose-response curve for d-tubocurarine based on body weight was determined for 44 infants and children 1 day to 7 years of age during halothane, nitrous oxide and oxygen anesthesia. Depression of thumb adduction was measured. Age difference did not affect the mean dose-effect response. Infants less than 10 days old, however, showed the wideest deviation of responses. When the effect of d-tubocurarine is determined by twitch response, infants and children are more resistant to d-tubocurarine and recover faster than adults from similar levels of neuromuscular depression. Monitoring of neuromuscular function by train-of-four stimulation proved as useful as it is in adults. |
| Alternate Journal | Anesthesiology |
| PubMed ID | 170845 |