|Title||Re-evaluation of dosage and duration of action of d-tubocurarine in the pediatric age group.|
|Publication Type||Journal Article|
|Year of Publication||1975|
|Authors||Goudsouzian NG, Donlon JV, Savarese JJ, Ryan JF|
|Date Published||1975 Oct|
|Keywords||Age Factors, Body Weight, Child, Child, Preschool, Dose-Response Relationship, Drug, Halothane, Humans, Infant, Infant, Newborn, Neuromuscular Junction, Nitrous Oxide, Synaptic Transmission, Time Factors, Tubocurarine|
A cumulative dose-response curve for d-tubocurarine based on body weight was determined for 44 infants and children 1 day to 7 years of age during halothane, nitrous oxide and oxygen anesthesia. Depression of thumb adduction was measured. Age difference did not affect the mean dose-effect response. Infants less than 10 days old, however, showed the wideest deviation of responses. When the effect of d-tubocurarine is determined by twitch response, infants and children are more resistant to d-tubocurarine and recover faster than adults from similar levels of neuromuscular depression. Monitoring of neuromuscular function by train-of-four stimulation proved as useful as it is in adults.