Department of Anesthesiology

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NCAM and vesicle cycling: the importance of good glue in the long run.

TitleNCAM and vesicle cycling: the importance of good glue in the long run.
Publication TypeJournal Article
Year of Publication2001
AuthorsRyan TA
JournalNeuron
Volume32
Issue5
Pagination759-61
Date Published2001 Dec 6
ISSN0896-6273
KeywordsAnimals, Humans, Neural Cell Adhesion Molecules, Synaptic Transmission, Synaptic Vesicles
Abstract

Careful functional dissection of mouse neuromuscular junctions (NMJs) formed in the absence of NCAM reveal that in spite of relatively normal morphology and ultrastructure, the presynaptic terminals have profound alterations in the mechanisms of recycling of synaptic vesicles. These alterations, including the appearance of a brefeldin-sensitive pathway, leave synaptic transmission impaired for certain types of activity. NCAMs thus appear to play a critical role in the molecular organization and function of synaptic terminals.

Alternate JournalNeuron
PubMed ID11738020