We are seeing patients in-person and through Video Visits. Learn more about how we’re keeping you safe and please review our updated visitor policy. Please also consider supporting Weill Cornell Medicine’s efforts to support our front-line workers.
Department of Anesthesiology

You are here

Metocurine in infants and children: neuromuscular and clinical effects.

TitleMetocurine in infants and children: neuromuscular and clinical effects.
Publication TypeJournal Article
Year of Publication1978
AuthorsGoudsouzian NG, Liu LM, Savarese JJ
Date Published1978 Oct
KeywordsBlood Pressure, Child, Child, Preschool, Dose-Response Relationship, Drug, Halothane, Heart Rate, Humans, Infant, Infant, Newborn, Neuromuscular Junction, Nitrous Oxide, Thiopental, Tubocurarine

A cumulative dose--response curve for metocurine based on body weight was determined in 30 infants and children during halothane (1.2 per cent inspired), nitrous oxide and oxygen (60/40 per cent) anesthesia. The mean and range of twitch depression and time for recovery from maximal neuromuscular blockade were not significantly different over an age range from newborn to 7 years. Metocurine is twice as potent as d-tubocurarine in children, and their requirement is more than that for adults. The rate of recovery from metocurine in children was the same as that from d-tubocurarine. In another 30 children, use of metocurine at a large dose (0.5 mg/kg) for endotracheal intubation caused no significant change in blood pressure or pulse rate. Cardial arrhythmias were not seen.

Alternate JournalAnesthesiology
PubMed ID697081