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Department of Anesthesiology

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Massive pulmonary embolism in pregnancy treated with catheter-directed tissue plasminogen activator.

TitleMassive pulmonary embolism in pregnancy treated with catheter-directed tissue plasminogen activator.
Publication TypeJournal Article
Year of Publication2015
AuthorsPick J, Berlin D, Horowitz J, Winokur R, Sista AK, Lichtman AD
JournalA A Case Rep
Volume4
Issue7
Pagination91-4
Date Published2015 Apr 1
ISSN2325-7237
KeywordsAdult, Female, Fibrinolytic Agents, Heparin, Low-Molecular-Weight, Humans, Pregnancy, Pregnancy Complications, Cardiovascular, Pregnancy Outcome, Pregnancy Trimester, Third, Pulmonary Embolism, Thrombolytic Therapy, Tissue Plasminogen Activator, Vascular Access Devices
Abstract

Pulmonary embolism is a leading cause of maternal death in the United States, contributing to the death of approximately 2 women per 100,000 live births each year. Thrombosis during pregnancy traditionally is treated conservatively with unfractionated heparin or low-molecular-weight heparin; however, cardiovascular collapse associated with a large pulmonary embolus may require immediate aggressive intervention to save the mother and fetus. We report the use of catheter infusion thrombolysis in the successful management of a third-trimester pregnant patient with a hemodynamically significant saddle pulmonary embolus.

DOI10.1213/XAA.0000000000000128
Alternate JournalA A Case Rep
PubMed ID25827861