|Title||General anesthetic effects on protein kinase C.|
|Publication Type||Journal Article|
|Year of Publication||1998|
|Date Published||1998 Nov 23|
|Keywords||Anesthetics, General, Animals, Brain, Protein Kinase C, Rats, Synaptosomes|
(1) Protein kinase C is a family of phospholipid-dependent protein kinases which are involved in the regulation of diverse cellular functions. (2) Evidence is emerging that certain general anesthetics can stimulate the activity of protein kinase C by interacting with the regulatory domain of the enzyme, possibly with the diacylglycerol binding sites. Anesthetics also potentiate activation-dependent down-regulation of the enzyme. (3) A role for PKC in the mediation and or modulation of the cellular effects of general anesthetics is a potential molecular target for anesthetic action.
|Alternate Journal||Toxicol. Lett.|
|Grant List||GM 52441 / GM / NIGMS NIH HHS / United States|