General anesthetic effects on protein kinase C.

TitleGeneral anesthetic effects on protein kinase C.
Publication TypeJournal Article
Year of Publication1998
AuthorsHemmings HC
JournalToxicol Lett
Date Published1998 Nov 23
KeywordsAnesthetics, General, Animals, Brain, Protein Kinase C, Rats, Synaptosomes

(1) Protein kinase C is a family of phospholipid-dependent protein kinases which are involved in the regulation of diverse cellular functions. (2) Evidence is emerging that certain general anesthetics can stimulate the activity of protein kinase C by interacting with the regulatory domain of the enzyme, possibly with the diacylglycerol binding sites. Anesthetics also potentiate activation-dependent down-regulation of the enzyme. (3) A role for PKC in the mediation and or modulation of the cellular effects of general anesthetics is a potential molecular target for anesthetic action.

Alternate JournalToxicol. Lett.
PubMed ID10049186
Grant ListGM 52441 / GM / NIGMS NIH HHS / United States