Department of Anesthesiology

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General anesthetic effects on protein kinase C.

TitleGeneral anesthetic effects on protein kinase C.
Publication TypeJournal Article
Year of Publication1998
AuthorsHemmings HC
JournalToxicol Lett
Volume100-101
Pagination89-95
Date Published1998 Nov 23
ISSN0378-4274
KeywordsAnesthetics, General, Animals, Brain, Protein Kinase C, Rats, Synaptosomes
Abstract

(1) Protein kinase C is a family of phospholipid-dependent protein kinases which are involved in the regulation of diverse cellular functions. (2) Evidence is emerging that certain general anesthetics can stimulate the activity of protein kinase C by interacting with the regulatory domain of the enzyme, possibly with the diacylglycerol binding sites. Anesthetics also potentiate activation-dependent down-regulation of the enzyme. (3) A role for PKC in the mediation and or modulation of the cellular effects of general anesthetics is a potential molecular target for anesthetic action.

Alternate JournalToxicol. Lett.
PubMed ID10049186
Grant ListGM 52441 / GM / NIGMS NIH HHS / United States