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Department of Anesthesiology

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General anesthesia for cesarean delivery in a patient with paroxysmal nocturnal hemoglobinuria and thrombocytopenia.

TitleGeneral anesthesia for cesarean delivery in a patient with paroxysmal nocturnal hemoglobinuria and thrombocytopenia.
Publication TypeJournal Article
Year of Publication2004
AuthorsKjaer K, Comerford M, Gadalla F
JournalAnesth Analg
Volume98
Issue5
Pagination1471-2, table of contents
Date Published2004 May
ISSN0003-2999
KeywordsAdult, Anesthesia, General, Anesthesia, Obstetrical, Cesarean Section, Female, Hemoglobinuria, Paroxysmal, Humans, Male, Pregnancy, Pregnancy Outcome, Thrombocytopenia
Abstract

UNLABELLED: Pregnancy in patients with paroxysmal nocturnal hemoglobinuria (PNH) increases the risk of complement activation, hemolysis, and thrombosis. We describe the anesthetic management of a patient with PNH who underwent general anesthesia for cesarean delivery. Steroids, heparin, and blood products were administered early to minimize the likelihood of a hematologic emergency.

IMPLICATIONS: Pregnancy in patients with paroxysmal nocturnal hemoglobinuria increases the risk of hemolysis, thrombosis, anemia, and thrombocytopenia. We describe the anesthetic management of a patient with paroxysmal nocturnal hemoglobinuria and thrombocytopenia who underwent general anesthesia for cesarean delivery.

Alternate JournalAnesth. Analg.
PubMed ID15105233