| Title | Effect of chronic pre- and post-natal low-dose ethanol exposure on brain enolase isoenzyme activities. |
| Publication Type | Journal Article |
| Year of Publication | 1992 |
| Authors | Harada K, Adams V, Okamoto M |
| Journal | Brain Res |
| Volume | 580 |
| Issue | 1-2 |
| Pagination | 334-7 |
| Date Published | 1992 May 15 |
| ISSN | 0006-8993 |
| Keywords | Animals, Brain, Ethanol, Female, Lactation, Maternal-Fetal Exchange, Nerve Tissue Proteins, Phosphopyruvate Hydratase, Pregnancy, Rats, Rats, Inbred Strains, Time Factors |
| Abstract | Sprague-Dawley dams were treated with 3 v/v % ethanol in liquid diet from the 8th day gestation through 3 weeks nursing period. Offsprings, ages 1, 2 and 3 weeks, and their dams were studied. Brain weights and their total proteins were not affected by this ethanol treatment. Total enolase activity/mg protein and its isoenzymes, i.e. non-neuron-specific, hybrid and neuron-specific, (mumol/min/mg protein) in 100,000 g supernate, were significantly lower in the treated. Additionally, enolase isoenzyme transformation was delayed. |
| Alternate Journal | Brain Res. |
| PubMed ID | 1504810 |
| Grant List | AA-07722 / AA / NIAAA NIH HHS / United States |