Department of Anesthesiology

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Effect of chronic pre- and post-natal low-dose ethanol exposure on brain enolase isoenzyme activities.

TitleEffect of chronic pre- and post-natal low-dose ethanol exposure on brain enolase isoenzyme activities.
Publication TypeJournal Article
Year of Publication1992
AuthorsHarada K, Adams V, Okamoto M
JournalBrain Res
Volume580
Issue1-2
Pagination334-7
Date Published1992 May 15
ISSN0006-8993
KeywordsAnimals, Brain, Ethanol, Female, Lactation, Maternal-Fetal Exchange, Nerve Tissue Proteins, Phosphopyruvate Hydratase, Pregnancy, Rats, Rats, Inbred Strains, Time Factors
Abstract

Sprague-Dawley dams were treated with 3 v/v % ethanol in liquid diet from the 8th day gestation through 3 weeks nursing period. Offsprings, ages 1, 2 and 3 weeks, and their dams were studied. Brain weights and their total proteins were not affected by this ethanol treatment. Total enolase activity/mg protein and its isoenzymes, i.e. non-neuron-specific, hybrid and neuron-specific, (mumol/min/mg protein) in 100,000 g supernate, were significantly lower in the treated. Additionally, enolase isoenzyme transformation was delayed.

Alternate JournalBrain Res.
PubMed ID1504810
Grant ListAA-07722 / AA / NIAAA NIH HHS / United States