Department of Anesthesiology

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DARPP-32 as a marker for D-1 dopaminoceptive cells in the rat brain: prenatal development and presence in glial elements (tanycytes) in the basal hypothalamus.

TitleDARPP-32 as a marker for D-1 dopaminoceptive cells in the rat brain: prenatal development and presence in glial elements (tanycytes) in the basal hypothalamus.
Publication TypeJournal Article
Year of Publication1988
AuthorsHökfelt T, Foster G, Schultzberg M, Meister B, Schalling M, Goldstein M, Hemmings HC, Ouimet C, Greengard P
JournalAdv Exp Med Biol
Volume235
Pagination65-82
Date Published1988
ISSN0065-2598
KeywordsAnimals, Brain, Dopamine and cAMP-Regulated Phosphoprotein 32, Hypothalamus, Nerve Tissue Proteins, Neuroglia, Phosphoproteins, Rats, Receptors, Dopamine, Receptors, Dopamine D1
Abstract

The present article reviews some aspects of the localization of a dopamine- and cyclic AMP-regulated phosphoprotein, DARPP-32, which is assumed to be present in D-1 dopaminoceptive neurons. Its prenatal development starts at day 14 of gestation, is to a large extent complete at birth and seems to be independent of ingrowing dopamine-containing afferents. Rearrangements occur in certain areas, and in some systems DARPP-32 appears to be only transiently expressed. The presence of DARPP-32 in glial structures, the tanycytes, in the arcuate nucleus-median eminence complex in the mediobasal hypothalamus, has given further support to the hypothesis that dopamine, by controlling the shape of the tanycytes and the extension of their processes, can regulate LHRH release by a 'mechanical mechanism'. This hypothesis is now being examined in some experimental paradigms.

Alternate JournalAdv. Exp. Med. Biol.
PubMed ID2976255
Grant ListMH17387 / MH / NIMH NIH HHS / United States
NS-08440 / NS / NINDS NIH HHS / United States
NS06801 / NS / NINDS NIH HHS / United States