Department of Anesthesiology

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Convergent mechanisms mediate preparatory states and repetition priming in the feeding network of Aplysia.

TitleConvergent mechanisms mediate preparatory states and repetition priming in the feeding network of Aplysia.
Publication TypeJournal Article
Year of Publication2003
AuthorsProekt A, Weiss KR
JournalJ Neurosci
Volume23
Issue10
Pagination4029-33
Date Published2003 May 15
ISSN1529-2401
KeywordsAnimals, Aplysia, Appetitive Behavior, Contingent Negative Variation, Evoked Potentials, Motor, Evoked Potentials, Somatosensory, Feeding Behavior, Interneurons, Long-Term Potentiation, Motor Neurons, Mouth Mucosa, Nerve Net, Patch-Clamp Techniques, Presynaptic Terminals, Reaction Time, Reflex, Monosynaptic, Serotonin, Synaptic Transmission
Abstract

Improvement of behavioral responses to expected stimuli has been attributed to a change in the preparatory state. In this study, we take advantage of the accessibility of the nervous system of Aplysia and develop an in vitro analog of the preparatory state for feeding behaviors. We provide evidence that the change in the preparatory state may be elicited initially by activity of identified serotonergic metacerebral cells (MCCs). We demonstrate, however, that the preparatory state is maintained through MCC-independent repetition priming that is embedded in the properties of the behavior-generating network. Both MCC-dependent and MCC-independent processes converge on the same site in the behavior-generating network to mediate the change in the preparatory state. Thus, we propose a model of how multiple neuronal structures interact to elicit and maintain changes in the preparatory states in the CNS.

Alternate JournalJ. Neurosci.
PubMed ID12764089
Grant ListMH35564 / MH / NIMH NIH HHS / United States
MH50235 / MH / NIMH NIH HHS / United States