Department of Anesthesiology

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A pre-synaptic to-do list for coupling exocytosis to endocytosis.

TitleA pre-synaptic to-do list for coupling exocytosis to endocytosis.
Publication TypeJournal Article
Year of Publication2006
AuthorsRyan TA
JournalCurr Opin Cell Biol
Volume18
Issue4
Pagination416-21
Date Published2006 Aug
ISSN0955-0674
KeywordsAnimals, Cell Membrane, Endocytosis, Exocytosis, Membrane Proteins, Models, Biological, Presynaptic Terminals, Synaptic Vesicles
Abstract

Synaptic vesicles are made locally in the nerve terminal during recycling of membrane. Synaptic vesicle proteins must be sorted and concentrated on the plasma membrane, packaged into a budding vesicle of precise size and cut away from the synaptic surface. Adaptors, scaffolds, BAR-domain and ENTH-domain proteins all must be coordinated to carry out this sequence of events prior to the action of dynamin. Details of how this is orchestrated at nerve terminals are just beginning to emerge.

DOI10.1016/j.ceb.2006.06.013
Alternate JournalCurr. Opin. Cell Biol.
PubMed ID16806881
Grant ListR01 NS036942 / NS / NINDS NIH HHS / United States