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The efficiency of the synaptic vesicle cycle at central nervous system synapses.

TitleThe efficiency of the synaptic vesicle cycle at central nervous system synapses.
Publication TypeJournal Article
Year of Publication2006
AuthorsFernandez-Alfonso T, Ryan TA
JournalTrends Cell Biol
Date Published2006 Aug
KeywordsAnimals, Central Nervous System, Endocytosis, Exocytosis, Hippocampus, Humans, Models, Neurological, Synapses, Synaptic Transmission, Synaptic Vesicles

Presynaptic nerve terminals rely heavily on membrane traffic to maintain efficient neurotransmission between cells. It is often assumed that, as neurons can fire action potentials at high frequency, the cell biological machinery for vesicle cycling must be highly specialized. Here, we examine the demands that are placed on the recycling machinery in three model systems used to characterize vertebrate vesicle recycling--small hippocampal synapses, calyx-type brainstem synapses, and ribbon-type sensory synapses--and the molecular pathways thought to underlie certain aspects of the vesicle cycle.

Alternate JournalTrends Cell Biol.
PubMed ID16839766
Grant ListR01 NS036942 / NS / NINDS NIH HHS / United States