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Department of Anesthesiology

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The effects of intraventricular injections of bombesin on temperature selection in the rat.

TitleThe effects of intraventricular injections of bombesin on temperature selection in the rat.
Publication TypeJournal Article
Year of Publication1990
AuthorsStump BS, McCoy JG, Avery DD
JournalBrain Res Bull
Date Published1990 Jul
KeywordsAnimals, Behavior, Animal, Body Temperature, Bombesin, Choice Behavior, Injections, Intraventricular, Male, Motor Activity, Peptides, Rats, Rats, Inbred Strains, Temperature

The purpose of these experiments was to elucidate further the possibility that intraventricular injections of bombesin (BBS) lower the set point around which an animal regulates its core body temperature. In an attempt to prevent a confounding of general activity and thermoregulatory behavior which occurred in earlier work, a horizontal temperature gradient was used. Intraventricular injections of bombesin resulted in the selection of temperatures that were approximately 9-13 degrees C colder than those selected by animals following control injections. Additionally, the increase in core body temperature observed following control injections was reversed by the highest dose of bombesin. No significant alterations in general locomotor activity were observed. These findings suggest that bombesin may act centrally to reduce the set point around which behavioral responses are regulated.

Alternate JournalBrain Res. Bull.
PubMed ID2207705