Department of Anesthesiology

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The cognitive cost of sleep lost.

TitleThe cognitive cost of sleep lost.
Publication TypeJournal Article
Year of Publication2011
AuthorsMcCoy JG, Strecker RE
JournalNeurobiol Learn Mem
Volume96
Issue4
Pagination564-82
Date Published2011 Nov
ISSN1095-9564
KeywordsAttention, Brain, Cognition, Cognition Disorders, Humans, Neuropsychological Tests, Sleep, Sleep Deprivation
Abstract

A substantial body of literature supports the intuitive notion that a good night's sleep can facilitate human cognitive performance the next day. Deficits in attention, learning & memory, emotional reactivity, and higher-order cognitive processes, such as executive function and decision making, have all been documented following sleep disruption in humans. Thus, whilst numerous clinical and experimental studies link human sleep disturbance to cognitive deficits, attempts to develop valid and reliable rodent models of these phenomena are fewer, and relatively more recent. This review focuses primarily on the cognitive impairments produced by sleep disruption in rodent models of several human patterns of sleep loss/sleep disturbance. Though not an exclusive list, this review will focus on four specific types of sleep disturbance: total sleep deprivation, experimental sleep fragmentation, selective REM sleep deprivation, and chronic sleep restriction. The use of rodent models can provide greater opportunities to understand the neurobiological changes underlying sleep loss induced cognitive impairments. Thus, this review concludes with a description of recent neurobiological findings concerning the neuroplastic changes and putative brain mechanisms that may underlie the cognitive deficits produced by sleep disturbances.

DOI10.1016/j.nlm.2011.07.004
Alternate JournalNeurobiol Learn Mem
PubMed ID21875679
PubMed Central IDPMC3614362
Grant ListHL060292 / HL / NHLBI NIH HHS / United States
HL095491 / HL / NHLBI NIH HHS / United States
MH039683 / MH / NIMH NIH HHS / United States
P01 HL095491 / HL / NHLBI NIH HHS / United States
P50 HL060292 / HL / NHLBI NIH HHS / United States
R01 MH039683 / MH / NIMH NIH HHS / United States