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Structures of proteins of biomedical interest from the Center for Eukaryotic Structural Genomics.

TitleStructures of proteins of biomedical interest from the Center for Eukaryotic Structural Genomics.
Publication TypeJournal Article
Year of Publication2007
AuthorsPhillips GN, Fox BG, Markley JL, Volkman BF, Bae E, Bitto E, Bingman CA, Frederick RO, McCoy JG, Lytle BL, Pierce BS, Song J, Twigger SN
JournalJ Struct Funct Genomics
Volume8
Issue2-3
Pagination73-84
Date Published2007 Sep
ISSN1345-711X
KeywordsCrystallography, X-Ray, Genomics, Humans, Nuclear Magnetic Resonance, Biomolecular, Proteins
Abstract

The Center for Eukaryotic Structural Genomics (CESG) produces and solves the structures of proteins from eukaryotes. We have developed and operate a pipeline to both solve structures and to test new methodologies. Both NMR and X-ray crystallography methods are used for structure solution. CESG chooses targets based on sequence dissimilarity to known structures, medical relevance, and nominations from members of the scientific community. Many times proteins qualify in more than one of these categories. Here we review some of the structures that have connections to human health and disease.

DOI10.1007/s10969-007-9023-6
Alternate JournalJ. Struct. Funct. Genomics
PubMed ID17786587
Grant ListF32 GM074385 / GM / NIGMS NIH HHS / United States
GM50853 / GM / NIGMS NIH HHS / United States
HG002760 / HG / NHGRI NIH HHS / United States
LM007359 / LM / NLM NIH HHS / United States
P50 GM064598 / GM / NIGMS NIH HHS / United States
U54 GM074901 / GM / NIGMS NIH HHS / United States