Department of Anesthesiology

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Structural correlates of selectivity and inactivation in potassium channels.

TitleStructural correlates of selectivity and inactivation in potassium channels.
Publication TypeJournal Article
Year of Publication2012
AuthorsMcCoy JG, Nimigean CM
JournalBiochim Biophys Acta
Volume1818
Issue2
Pagination272-85
Date Published2012 Feb
ISSN0006-3002
KeywordsAmino Acid Sequence, Animals, Humans, Models, Molecular, Molecular Sequence Data, Potassium Channels, Protein Structure, Secondary, Sequence Alignment
Abstract

Potassium channels are involved in a tremendously diverse range of physiological applications requiring distinctly different functional properties. Not surprisingly, the amino acid sequences for these proteins are diverse as well, except for the region that has been ordained the "selectivity filter". The goal of this review is to examine our current understanding of the role of the selectivity filter and regions adjacent to it in specifying selectivity as well as its role in gating/inactivation and possible mechanisms by which these processes are coupled. Our working hypothesis is that an amino acid network behind the filter modulates selectivity in channels with the same signature sequence while at the same time affecting channel inactivation properties. This article is part of a Special Issue entitled: Membrane protein structure and function.

DOI10.1016/j.bbamem.2011.09.007
Alternate JournalBiochim. Biophys. Acta
PubMed ID21958666
PubMed Central IDPMC3253935
Grant ListR01 GM088352 / GM / NIGMS NIH HHS / United States
R01 GM088352-01 / GM / NIGMS NIH HHS / United States
R01 GM088352-02 / GM / NIGMS NIH HHS / United States
R01 GM088352-03 / GM / NIGMS NIH HHS / United States