Department of Anesthesiology

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Recovery of consciousness is mediated by a network of discrete metastable activity states.

TitleRecovery of consciousness is mediated by a network of discrete metastable activity states.
Publication TypeJournal Article
Year of Publication2014
AuthorsHudson AE, Calderon DPaola, Pfaff DW, Proekt A
JournalProc Natl Acad Sci U S A
Volume111
Issue25
Pagination9283-8
Date Published2014 Jun 24
ISSN1091-6490
KeywordsAnimals, Coma, Consciousness, Nerve Net, Rats
Abstract

It is not clear how, after a large perturbation, the brain explores the vast space of potential neuronal activity states to recover those compatible with consciousness. Here, we analyze recovery from pharmacologically induced coma to show that neuronal activity en route to consciousness is confined to a low-dimensional subspace. In this subspace, neuronal activity forms discrete metastable states persistent on the scale of minutes. The network of transitions that links these metastable states is structured such that some states form hubs that connect groups of otherwise disconnected states. Although many paths through the network are possible, to ultimately enter the activity state compatible with consciousness, the brain must first pass through these hubs in an orderly fashion. This organization of metastable states, along with dramatic dimensionality reduction, significantly simplifies the task of sampling the parameter space to recover the state consistent with wakefulness on a physiologically relevant timescale.

DOI10.1073/pnas.1408296111
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID24927558
PubMed Central IDPMC4078822
Grant ListGM106144-01 / GM / NIGMS NIH HHS / United States