|Title||Potential clinical uses of short-acting nondepolarizing neuromuscular-blocking agents as predicted from animal experiments.|
|Publication Type||Journal Article|
|Year of Publication||1975|
|Authors||Savarese JJ, Antonio RP, Ginsburg S|
|Date Published||1975 Sep-Oct|
|Keywords||Animals, Cats, Dogs, Drug Interactions, Haplorhini, Neuromuscular Nondepolarizing Agents, Pain, Potassium, Quaternary Ammonium Compounds, Succinylcholine, Time Factors, Tubocurarine|
It is readily evident that a short-acting nondepolarizing agent suitable for clinical use would be of value in anesthesiology. The most commonly used short-acting relaxant, succinylcholine, is a depolarizing drug, with all the side effects inherent in such agents. The authors have investigated the actions of several short-acting nondepolarizing ester neuromuscular-blocking drug in comparison with succinylcholine, and theri interactions with d-tubocurarine, and inhibitors of true and plasma cholinesterase. Two experimental agents, HH-85 and JJ-142, are examples. Tests in animals suggest areas of extrapolation to human use.
|Alternate Journal||Anesth. Analg.|