Department of Anesthesiology

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One week of exposure to intermittent hypoxia impairs attentional set-shifting in rats.

TitleOne week of exposure to intermittent hypoxia impairs attentional set-shifting in rats.
Publication TypeJournal Article
Year of Publication2010
AuthorsMcCoy JG, McKenna JT, Connolly NP, Poeta DL, Ling L, McCarley RW, Strecker RE
JournalBehav Brain Res
Volume210
Issue1
Pagination123-6
Date Published2010 Jun 26
ISSN1872-7549
KeywordsAnimals, Anoxia, Attention, Cognition, Cognition Disorders, Discrimination (Psychology), Disease Models, Animal, Executive Function, Learning, Male, Memory, Short-Term, Motor Activity, Neuropsychological Tests, Random Allocation, Rats, Rats, Inbred F344, Sleep Apnea Syndromes, Time Factors
Abstract

Intermittent hypoxia (IH), a characteristic of sleep apnea, was modeled in Fischer Brown Norway rats (10h/day for 7 days) followed by cognitive testing in an attentional set-shifting task. The ability to shift attention from one sensory modality (e.g., odor) to another (e.g., digging medium) was impaired, a finding that could not be attributed to deficits in attention, discrimination, learning, or motor performance. Instead, the deficit is likely to reflect impaired allocation of attentional resources of the working memory system.

DOI10.1016/j.bbr.2010.01.043
Alternate JournalBehav. Brain Res.
PubMed ID20122971
PubMed Central IDPMC2866501
Grant ListF32 MH070156-01A1 / MH / NIMH NIH HHS / United States
NIH F32 MH070156 / MH / NIMH NIH HHS / United States
NIH HL060292 / HL / NHLBI NIH HHS / United States
NIH T32 HL07901 / HL / NHLBI NIH HHS / United States
P50 HL060292-10 / HL / NHLBI NIH HHS / United States
T32 HL007901-01 / HL / NHLBI NIH HHS / United States