Title | One week of exposure to intermittent hypoxia impairs attentional set-shifting in rats. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | McCoy JG, McKenna JT, Connolly NP, Poeta DL, Ling L, McCarley RW, Strecker RE |
Journal | Behav Brain Res |
Volume | 210 |
Issue | 1 |
Pagination | 123-6 |
Date Published | 2010 Jun 26 |
ISSN | 1872-7549 |
Keywords | Animals, Anoxia, Attention, Cognition, Cognition Disorders, Discrimination (Psychology), Disease Models, Animal, Executive Function, Learning, Male, Memory, Short-Term, Motor Activity, Neuropsychological Tests, Random Allocation, Rats, Rats, Inbred F344, Sleep Apnea Syndromes, Time Factors |
Abstract | Intermittent hypoxia (IH), a characteristic of sleep apnea, was modeled in Fischer Brown Norway rats (10h/day for 7 days) followed by cognitive testing in an attentional set-shifting task. The ability to shift attention from one sensory modality (e.g., odor) to another (e.g., digging medium) was impaired, a finding that could not be attributed to deficits in attention, discrimination, learning, or motor performance. Instead, the deficit is likely to reflect impaired allocation of attentional resources of the working memory system. |
DOI | 10.1016/j.bbr.2010.01.043 |
Alternate Journal | Behav. Brain Res. |
PubMed ID | 20122971 |
PubMed Central ID | PMC2866501 |
Grant List | F32 MH070156-01A1 / MH / NIMH NIH HHS / United States NIH F32 MH070156 / MH / NIMH NIH HHS / United States NIH HL060292 / HL / NHLBI NIH HHS / United States NIH T32 HL07901 / HL / NHLBI NIH HHS / United States P50 HL060292-10 / HL / NHLBI NIH HHS / United States T32 HL007901-01 / HL / NHLBI NIH HHS / United States |