Department of Anesthesiology

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Multiple contributions of an input-representing neuron to the dynamics of the aplysia feeding network.

TitleMultiple contributions of an input-representing neuron to the dynamics of the aplysia feeding network.
Publication TypeJournal Article
Year of Publication2007
AuthorsProekt A, Jing J, Weiss KR
JournalJ Neurophysiol
Volume97
Issue4
Pagination3046-56
Date Published2007 Apr
ISSN0022-3077
KeywordsAnimals, Aplysia, Electric Stimulation, Feeding Behavior, Instinct, Interneurons, Nerve Net, Neural Pathways, Neurons
Abstract

In Aplysia, mutually antagonistic ingestive and egestive behaviors are produced by the same multifunctional central pattern generator (CPG) circuit. Interestingly, higher-order inputs that activate the CPG do not directly specify whether the resulting motor program is ingestive or egestive because the slow dynamics of the network intervene. One input, the commandlike cerebral-buccal interneuron 2 (CBI-2), slowly drives the motor output toward ingestion, whereas another input, the esophageal nerve (EN), drives the motor output toward egestion. When the input is switched from EN to CBI-2, the motor output does not switch immediately and remains egestive. Here, we investigated how these slow dynamics are implemented on the interneuronal level. We found that activity of two CPG interneurons, B20 and B40, tracked the motor output regardless of the input, whereas activity of another CPG interneuron, B65, tracked the input regardless of the motor output. Furthermore, we show that the slow dynamics of the network are implemented, at least in part, in the slow dynamics of the interaction between the input-representing and the output-representing neurons. We conclude that 1) a population of CPG interneurons, recruited during a particular motor program, simultaneously encodes both the input that is used to elicit the motor program and the output elicited by this input; and 2) activity of the input-representing neurons may serve to bias the future motor programs.

DOI10.1152/jn.01301.2006
Alternate JournalJ. Neurophysiol.
PubMed ID17314236
Grant ListMH-036730 / MH / NIMH NIH HHS / United States