Department of Anesthesiology

You are here

Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland.

TitleIdentification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland.
Publication TypeJournal Article
Year of Publication1991
AuthorsMeister B, Askergren J, Tunevall G, Hemmings HC, Greengard P
JournalJ Endocrinol Invest
Volume14
Issue8
Pagination655-61
Date Published1991 Sep
ISSN0391-4097
KeywordsAdenoma, Cyclic AMP, Dopamine, Dopamine and cAMP-Regulated Phosphoprotein 32, Fluorescent Antibody Technique, Humans, Molecular Weight, Nerve Tissue Proteins, Parathyroid Glands, Parathyroid Hormone, Parathyroid Neoplasms, Phosphoproteins
Abstract

The cellular localization of DARPP-32, a dopamine- and cyclic AMP-regulated phosphoprotein of 32 kD, enriched in dopamine-innervated brain regions, was investigated in the human parathyroid gland using indirect immunofluorescence histochemistry. Monoclonal antibodies were used to demonstrate DARPP-32-like immunoreactivity (LI) in chief cells of the normal human parathyroid gland and in cells of human parathyroid adenoma. Direct double-labelling revealed coexistence of DARPP-32-LI with parathyroid hormone (PTH)-LI. It has previously been demonstrated that dopamine D1-receptors are present in the parathyroid gland and that dopamine and D1-agonists stimulate the release of PTH. The present results suggest that DARPP-32 may play a role in the cellular mechanisms leading to dopamine-induced PTH secretion.

Alternate JournalJ. Endocrinol. Invest.
PubMed ID1663529
Grant ListMH40899 / MH / NIMH NIH HHS / United States
MH43230 / MH / NIMH NIH HHS / United States