Department of Anesthesiology

You are here

Vanessa Osman Awarded NIH NRSA Grant

Vanessa Osman, a pharmacology PhD student in the Hemmings lab, is the recipient of a National Research Service Award (NRSA) from the National Institutes of Health for her study of volatile anesthetics.

"Volatile anesthetics such as isoflurane are staples of modern medicine," writes Osman,"but despite their widespread clinical use their precise cellular and molecular mechanisms of action remain unclear.

In some patients, volatile anesthetics can cause the potentially fatal pharmacogenetic condition malignant hyperthermia (MH), characterized by hyperthermia, tachycardia, muscle rigidity, and hypermetabolism. While we understand isoflurane-induced MH mechanisms in skeletal muscle in reasonable detail, the effects of MH on neurons are unknown. In order to increase survival from this devastating complication, it is important to understand how volatile anesthetics such as isoflurane act on neurons, especially on MH relevant pathways. “

Vanessa’s research aims to aim to elucidate isoflurane’s neuronal mechanisms of action as well as the neuronal effects of isoflurane-induced malignant hyperthermia.




Contact Us

Dept. of Anesthesiology
NewYork-Presbyterian Hospital/Weill Cornell Medicine
525 East 68th Street, Box 124
New York, NY 10065
Fax: (212) 746-8563

Office of the Chair
Phone: (212) 746-2962
E-mail:  Marissa Matarazzo,

Residency and Fellowship Education
Direct all inquiries to:
Phone: (212) 746-2941
For trainee verification inquiries:

Patient Billing Inquiries
Phone: (855) 880-0343