Publications

Purtell K, Gingrich KJ, OuYang W, Herold KF, Hemmings HC.  2015.  Activity-dependent depression of neuronal sodium channels by the general anaesthetic isoflurane.. Br J Anaesth. 115(1):112-21.

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Calder EL, Tchieu J, Steinbeck JA, Tu E, Keros S, Ying S-W, Jaiswal MK, Cornacchia D, Goldstein PA, Tabar V et al..  2015.  Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation.. J Neurosci. 35(33):11462-81.

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Lolicato M, Riegelhaupt PM, Arrigoni C, Clark KA, Minor DL.  2014.  Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels.. Neuron. 84(6):1198-212.

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Kim SHyun, Ryan TA.  2013.  Balance of calcineurin Aα and CDK5 activities sets release probability at nerve terminals.. J Neurosci. 33(21):8937-50.

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Lafaille FG, Pessach IM, Zhang S-Y, Ciancanelli MJ, Herman M, Abhyankar A, Ying S-W, Keros S, Goldstein PA, Mostoslavsky G et al..  2012.  Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells.. Nature. 491(7426):769-73.

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Neumann S, Eliseeva E, McCoy JG, Napolitano G, Giuliani C, Monaco F, Huang W, Gershengorn MC.  2011.  A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor.. J Clin Endocrinol Metab. 96(2):548-54.

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Kanda VA, Purtell K, Abbott GW.  2011.  Protein kinase C downregulates I(Ks) by stimulating KCNQ1-KCNE1 potassium channel endocytosis.. Heart Rhythm. 8(10):1641-7.

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Bendor J, Lizardi-Ortiz JE, Westphalen RI, Brandstetter M, Hemmings HC, Sulzer D, Flajolet M, Greengard P.  2010.  AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.. EMBO J. 29(16):2813-26.

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Balaji J, Armbruster M, Ryan TA.  2008.  Calcium control of endocytic capacity at a CNS synapse.. J Neurosci. 28(26):6742-9.

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Fernandez-Alfonso T, Ryan TA.  2008.  A heterogeneous "resting" pool of synaptic vesicles that is dynamically interchanged across boutons in mammalian CNS synapses.. Brain Cell Biol. 36(1-4):87-100.

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Mani M, Lee SYoon, Lucast L, Cremona O, Di Paolo G, De Camilli P, Ryan TA.  2007.  The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals.. Neuron. 56(6):1004-18.

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Ouyang W, Hemmings HC.  2007.  Isoform-selective effects of isoflurane on voltage-gated Na+ channels.. Anesthesiology. 107(1):91-8.

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Balaji J, Ryan TA.  2007.  Single-vesicle imaging reveals that synaptic vesicle exocytosis and endocytosis are coupled by a single stochastic mode.. Proc Natl Acad Sci U S A. 104(51):20576-81.

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Atluri PP, Ryan TA.  2006.  The kinetics of synaptic vesicle reacidification at hippocampal nerve terminals.. J Neurosci. 26(8):2313-20.

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Fernandez-Alfonso T, Kwan R, Ryan TA.  2006.  Synaptic vesicles interchange their membrane proteins with a large surface reservoir during recycling.. Neuron. 51(2):179-86.

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Jia F, Pignataro L, Schofield CM, Yue M, Harrison NL, Goldstein PA.  2005.  An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons.. J Neurophysiol. 94(6):4491-501.

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Hemmings HC, Yan W, Westphalen RI, Ryan TA.  2005.  The general anesthetic isoflurane depresses synaptic vesicle exocytosis.. Mol Pharmacol. 67(5):1591-9.

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Mitchell SJ, Ryan TA.  2005.  Munc18-dependent regulation of synaptic vesicle exocytosis by syntaxin-1A in hippocampal neurons.. Neuropharmacology. 48(3):372-80.

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Fernandez-Alfonso T, Ryan TA.  2004.  The kinetics of synaptic vesicle pool depletion at CNS synaptic terminals.. Neuron. 41(6):943-53.

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Mitchell SJ, Ryan TA.  2004.  Syntaxin-1A is excluded from recycling synaptic vesicles at nerve terminals.. J Neurosci. 24(20):4884-8.

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Chi P, Greengard P, Ryan TA.  2003.  Synaptic vesicle mobilization is regulated by distinct synapsin I phosphorylation pathways at different frequencies.. Neuron. 38(1):69-78.

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Chi P, Greengard P, Ryan TA.  2001.  Synapsin dispersion and reclustering during synaptic activity.. Nat Neurosci. 4(12):1187-93.

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Ahmed ST, Ivashkiv LB.  2000.  Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways.. J Immunol. 165(9):5227-37.

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Sankaranarayanan S, Ryan TA.  2000.  Real-time measurements of vesicle-SNARE recycling in synapses of the central nervous system.. Nat Cell Biol. 2(4):197-204.

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Mayerhofer A, Hemmings HC, Snyder GL, Greengard P, Boddien S, Berg U, Brucker C.  1999.  Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro.. J Clin Endocrinol Metab. 84(1):257-64.

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