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Filters: Author is Heerdt, Paul M  [Clear All Filters]
2018
Kaullen JD, Owen JS, Brouwer KLR, Heerdt PM, Lien CA, Savarese JJ, Schmith VD.  2018.  Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers.. Anesthesiology. 128(6):1107-1116.
Savarese JJ, Sunaga H, McGilvra JD, Belmont MR, Murrell MT, Jeannotte E, Cooke FE, Wastila WB, Heerdt PM.  2018.  Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine.. Anesthesiology. 129(5):970-988.
2016
Heerdt PM, Sunaga H, Owen JS, Murrell MT, Malhotra JK, Godfrey D, Steinkamp M, Savard P, Savarese JJ, Lien CA.  2016.  Dose-response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man.. Anesthesiology. 125(6):1136-1143.
Sunaga H, Savarese JJ, McGilvra JD, Heerdt PM, Belmont MR, Van Ornum SG, Murrell MT, Malhotra JK, Savard PM, Jeannotte E et al..  2016.  Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine-Additional Studies of Safety and Efficacy in the Anesthetized Rhesus Monkey and Cat.. Anesthesiology. 125(4):732-743.
2015
Martin-Flores M, Cheetham J, Campoy L, Sakai DM, Heerdt PM, Gleed RD.  2015.  Effect of gantacurium on evoked laryngospasm and duration of apnea in anesthetized healthy cats.. Am J Vet Res. 76(3):216-23.
Heerdt PM, Sunaga H, Savarese JJ.  2015.  Novel neuromuscular blocking drugs and antagonists.. Curr Opin Anaesthesiol. 28(4):403-10.
2014
Diaz LL, Zhang J, Heerdt PM.  2014.  Comparative pharmacodynamics of pancuronium, cisatracurium, and CW002 in rabbits.. J Am Assoc Lab Anim Sci. 53(3):283-9.
2012
McGlothlin D, Ivascu N, Heerdt PM.  2012.  Anesthesia and pulmonary hypertension.. Prog Cardiovasc Dis. 55(2):199-217.
Heerdt PM, Kant R, Hu Z, Kanda VA, Christini DJ, Malhotra JK, Abbott GW.  2012.  Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy.. J Mol Cell Cardiol. 53(3):350-3.
2011
Anand SX, Viles-Gonzalez JF, Mahboobi SK, Heerdt PM.  2011.  Bivalirudin utilization in cardiac surgery: shifting anticoagulation from indirect to direct thrombin inhibition.. Can J Anaesth. 58(3):296-311.
Heerdt PM.  2011.  Letter to the editor: response to Ballestero et al.. Pediatr Cardiol. 32(6):866-7.
Heerdt PM, Wagner CL, DeMais M, Savarese JJ.  2011.  Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles.. J Pharmacol Toxicol Methods. 64(2):111-8.
2010
Sunaga H, Malhotra JK, Yoon E, Savarese JJ, Heerdt PM.  2010.  Cysteine reversal of the novel neuromuscular blocking drug CW002 in dogs: pharmacodynamics, acute cardiovascular effects, and preliminary toxicology.. Anesthesiology. 112(4):900-9.
Heerdt PM, Malhotra JK, Pan BY, Sunaga H, Savarese JJ.  2010.  Pharmacodynamics and cardiopulmonary side effects of CW002, a cysteine-reversible neuromuscular blocking drug in dogs.. Anesthesiology. 112(4):910-6.
Savarese JJ, McGilvra JD, Sunaga H, Belmont MR, Van Ornum SG, Savard PM, Heerdt PM.  2010.  Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011.. Anesthesiology. 113(1):58-73.
2009
Maslow A, Schwartz C, Mahmood F, Singh A, Heerdt PM.  2009.  Case report: paradoxical ventricular septal motion in the setting of primary right ventricular myocardial failure.. Can J Anaesth. 56(7):510-7.
Heerdt PM, Park BJ.  2009.  The emerging role of minimally invasive surgical techniques for the treatment of lung malignancy in the elderly.. Thorac Surg Clin. 19(3):345-51.
Pedoto A, Heerdt PM.  2009.  Postoperative care after pulmonary resection: postanesthesia care unit versus intensive care unit.. Curr Opin Anaesthesiol. 22(1):50-5.
2008
Platholi J, Heerdt PM, Tung HYLim, Hemmings HC.  2008.  Activation of brain protein phosphatase-1(I) following cardiac arrest and resuscitation involving an interaction with 14-3-3 gamma.. J Neurochem. 105(5):2029-38.
Heerdt PM, Park BJ.  2008.  The emerging role of minimally invasive surgical techniques for the treatment of lung malignancy in the elderly.. Anesthesiol Clin. 26(2):315-24,vi-vii.
Amar D, Desiderio DP, Heerdt PM, Kolker AC, Zhang H, Thaler HT.  2008.  Practice patterns in choice of left double-lumen tube size for thoracic surgery.. Anesth Analg. 106(2):379-83,tableofcontents.
Zhang TT, Platholi J, Heerdt PM, Hemmings HC, Tung HYL.  2008.  Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation.. Metab Brain Dis. 23(1):95-104.
Amar D, Heerdt PM, Desiderio DP, Kolker AC.  2008.  Re: Undersizing left double-lumen tubes.. Anesth Analg. 107(3):1082.
2007
S Bullock A, Platholi J, Gjyrezi A, Heerdt PM, Tung HYLim, Hemmings HC.  2007.  Differential regulation of protein phosphatase-1(I) by neurabin.. Biochem Biophys Res Commun. 358(1):140-4.
Amar D, Zhang H, Park B, Heerdt PM, Fleisher M, Thaler HT.  2007.  Inflammation and outcome after general thoracic surgery.. Eur J Cardiothorac Surg. 32(3):431-4.