Department of Anesthesiology

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Pseudocholinesterase hyperactivity with succinylcholine resistance: an unusual cause of difficult intubation.

TitlePseudocholinesterase hyperactivity with succinylcholine resistance: an unusual cause of difficult intubation.
Publication TypeJournal Article
Year of Publication1997
AuthorsYao FS, Savarese JJ
JournalJ Clin Anesth
Volume9
Issue4
Pagination328-30
Date Published1997 Jun
ISSN0952-8180
KeywordsAdult, Dilatation and Curettage, Drug Resistance, Female, Humans, Intubation, Intratracheal, Neuromuscular Depolarizing Agents, Pregnancy, Pregnancy, Ectopic, Pseudocholinesterase, Succinylcholine
Abstract

We describe a case of difficult intubation, possibly due to marked pseudocholinesterase hyperactivity that caused rapid inactivation of succinycholine. Possible causes of difficult intubation and pseudocholinesterase hyperactivity are discussed. Literature on genetic variants associated with markedly increased pseudocholinesterase activity are reviewed. It is concluded that pseudocholinesterase hyperactivity may be a rare cause of difficult intubation. We recommend that pseudocholinesterase activity should be determined in all patients who appear to be resistant to the action of normal doses of succinylcholine or mivacurium.

Alternate JournalJ Clin Anesth
PubMed ID9195358