Department of Anesthesiology

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Pharmacokinetics and pharmacodynamics of atracurium during isoflurane anesthesia in normal and anephric patients.

TitlePharmacokinetics and pharmacodynamics of atracurium during isoflurane anesthesia in normal and anephric patients.
Publication TypeJournal Article
Year of Publication1986
AuthorsdeBros FM, Lai A, Scott R, deBros J, Batson AG, Goudsouzian N, Ali HH, Cosimi AB, Savarese JJ
JournalAnesth Analg
Volume65
Issue7
Pagination743-6
Date Published1986 Jul
ISSN0003-2999
KeywordsAnesthesia, General, Atracurium, Humans, Injections, Intravenous, Isoflurane, Isoquinolines, Kinetics, Methyl Ethers, Nephrectomy
Abstract

We compared the pharmacokinetics and pharmacodynamics of atracurium in eight normal and eight anephric patients during isoflurane anesthesia. Plasma concentrations were measured by high performance liquid chromatography after a single injection of 0.5 mg/kg, and neuromuscular effects were evaluated by the single twitch method. With regard to pharmacokinetic or pharmacodynamic parameters, we found no statistically significant differences between normal and anephric patients. We conclude that during isoflurane anesthesia, anephric patients distribute and eliminate atracurium much as normal patients do.

Alternate JournalAnesth. Analg.
PubMed ID3755015