| Title | Metocurine in infants and children: neuromuscular and clinical effects. |
| Publication Type | Journal Article |
| Year of Publication | 1978 |
| Authors | Goudsouzian NG, Liu LM, Savarese JJ |
| Journal | Anesthesiology |
| Volume | 49 |
| Issue | 4 |
| Pagination | 266-9 |
| Date Published | 1978 Oct |
| ISSN | 0003-3022 |
| Keywords | Blood Pressure, Child, Child, Preschool, Dose-Response Relationship, Drug, Halothane, Heart Rate, Humans, Infant, Infant, Newborn, Neuromuscular Junction, Nitrous Oxide, Thiopental, Tubocurarine |
| Abstract | A cumulative dose--response curve for metocurine based on body weight was determined in 30 infants and children during halothane (1.2 per cent inspired), nitrous oxide and oxygen (60/40 per cent) anesthesia. The mean and range of twitch depression and time for recovery from maximal neuromuscular blockade were not significantly different over an age range from newborn to 7 years. Metocurine is twice as potent as d-tubocurarine in children, and their requirement is more than that for adults. The rate of recovery from metocurine in children was the same as that from d-tubocurarine. In another 30 children, use of metocurine at a large dose (0.5 mg/kg) for endotracheal intubation caused no significant change in blood pressure or pulse rate. Cardial arrhythmias were not seen. |
| Alternate Journal | Anesthesiology |
| PubMed ID | 697081 |