Department of Anesthesiology
Author Title Type [ Year(Asc)]
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2025
Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM.  2025.  Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel.. Nat Commun. 16(1):1769.
Gao S, Bibineyshvili Y, Safavynia SA, Calderón-Martínez J, Grinspan ZM, Calderon DP.  2025.  Cortical signatures linked to behavior quantitatively track arousal levels.. Proc Natl Acad Sci U S A. 122(19):e2413789122.
Riel EB, Bu W, Joseph TT, Khajoueinejad L, Eckenhoff RG, Riegelhaupt PM.  2025.  The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel.. Proc Natl Acad Sci U S A. 122(14):e2421654122.
Liou J-Y, M Maciver B, Sleigh JW.  2025.  Solving the enigma of burst suppression.. Br J Anaesth. 134(4):900-902.
Qi Y, Jang D, Ryu J, Bai T, Shin Y, Gu W, Iyer A, Li G, Ma H, Liou J-Y et al..  2025.  Stabilized carbon coating on microelectrodes for scalable and interoperable neurotransmitter sensing.. Nat Commun. 16(1):3300.
Lansky S, Wang Z, Clarke OB, Chipot C, Scheuring S.  2025.  Structural dynamics and permeability of the TRPV3 pentamer.. Nat Commun. 16(1):4520.
2024
Türkaydin B, Schewe M, Riel EBarbara, Schulz F, Biedermann J, Baukrowitz T, Sun H.  2024.  Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels.. Nat Commun. 15(1):4628.
Neelsen LC, Riel EB, Rinné S, Schmid F-R, Jürs BC, Bedoya M, Langer JP, Eymsh B, Kiper AK, Cordeiro S et al..  2024.  Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2.. Nat Commun. 15(1):7545.
2023
Osman V, Speigel I, Patel K, Hemmings HC.  2023.  Isoflurane Alters Presynaptic Endoplasmic Reticulum Calcium Dynamics in Wild-Type and Malignant Hyperthermia-Susceptible Rodent Hippocampal Neurons.. eNeuro. 10(8)
2022
Jiao F, Dehez F, Ni T, Yu X, Dittman JS, Gilbert R, Chipot C, Scheuring S.  2022.  Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism.. Nat Commun. 13(1):5039.
2021
Speigel IA, Hemmings HC.  2021.  Selective inhibition of gamma aminobutyric acid release from mouse hippocampal interneurone subtypes by the volatile anaesthetic isoflurane.. Br J Anaesth. 127(4):587-599.
2020
Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia BA, Nimigean CM, Eckenhoff RG, Riegelhaupt PM.  2020.  Mechanistic insights into volatile anesthetic modulation of K2P channels.. Elife. 9
2017
Herold KF, Andersen OS, Hemmings HC.  2017.  Divergent effects of anesthetics on lipid bilayer properties and sodium channel function.. Eur Biophys J. 46(7):617-626.
Menny A, Lefebvre SN, Schmidpeter PAm, Drège E, Fourati Z, Delarue M, Edelstein SJ, Nimigean CM, Joseph D, Corringer P-J.  2017.  Identification of a pre-active conformation of a pentameric channel receptor.. Elife. 6
2015
Purtell K, Gingrich KJ, OuYang W, Herold KF, Hemmings HC.  2015.  Activity-dependent depression of neuronal sodium channels by the general anaesthetic isoflurane.. Br J Anaesth. 115(1):112-21.
Accardi A.  2015.  CELL SIGNALING. Lipids link ion channels and cancer.. Science. 349(6250):789-90.
Martin-Flores M, Cheetham J, Campoy L, Sakai DM, Heerdt PM, Gleed RD.  2015.  Effect of gantacurium on evoked laryngospasm and duration of apnea in anesthetized healthy cats.. Am J Vet Res. 76(3):216-23.
Fischer KR, Durrans A, Lee S, Sheng J, Li F, Wong STC, Choi H, Rayes TEl, Ryu S, Troeger J et al..  2015.  Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance.. Nature. 527(7579):472-6.
Goldstein PA.  2015.  HCN1 Channels as Targets for Volatile Anesthetics: Coming to the Fore.. Anesth Analg. 121(3):594-6.
Mattusch C, Kratzer S, Buerge M, Kreuzer M, Engel T, Kopp C, Biel M, Hammelmann V, Ying S-W, Goldstein PA et al..  2015.  Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments.. Anesthesiology. 122(5):1047-59.
Baumgart JP, Zhou Z-Y, Hara M, Cook DC, Hoppa MB, Ryan TA, Hemmings HC.  2015.  Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca2+ influx, not Ca2+-exocytosis coupling.. Proc Natl Acad Sci U S A. 112(38):11959-64.
Solovey G, Alonso LM, Yanagawa T, Fujii N, Magnasco MO, Cecchi GA, Proekt A.  2015.  Loss of Consciousness Is Associated with Stabilization of Cortical Activity.. J Neurosci. 35(30):10866-77.
Hudson AE, Proekt A.  2015.  Some heightened sensitivity.. Br J Anaesth. 115 Suppl 1:i5-i8.
Picollo A, Malvezzi M, Accardi A.  2015.  TMEM16 proteins: unknown structure and confusing functions.. J Mol Biol. 427(1):94-105.
2014
Rangaraju V, Calloway N, Ryan TA.  2014.  Activity-driven local ATP synthesis is required for synaptic function.. Cell. 156(4):825-35.