Department of Anesthesiology
Author Title Type [ Year(Desc)]
Filters: Keyword is Binding Sites  [Clear All Filters]
2001
Jovanovic JN, Sihra TS, Nairn AC, Hemmings HC, Greengard P, Czernik AJ.  2001.  Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals.. J Neurosci. 21(20):7944-53.
2003
Sokolova O, Accardi A, Gutierrez D, Lau A, Rigney M, Grigorieff N.  2003.  Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit.. Proc Natl Acad Sci U S A. 100(22):12607-12.
Accardi A, Pusch M.  2003.  Conformational changes in the pore of CLC-0.. J Gen Physiol. 122(3):277-93.
Estévez R, Schroeder BC, Accardi A, Jentsch TJ, Pusch M.  2003.  Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1.. Neuron. 38(1):47-59.
Liantonio A, De Luca A, Pierno S, Didonna MPaola, Loiodice F, Fracchiolla G, Tortorella P, Antonio L, Bonerba E, Traverso S et al..  2003.  Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1.. Br J Pharmacol. 139(7):1255-64.
2004
Picollo A, Liantonio A, Didonna MPaola, Elia L, Camerino DConte, Pusch M.  2004.  Molecular determinants of differential pore blocking of kidney CLC-K chloride channels.. EMBO Rep. 5(6):584-9.
2005
Bitto E, Bingman CA, McCoy JG, Allard STM, Wesenberg GE, Phillips GN.  2005.  The structure at 1.6 Angstroms resolution of the protein product of the At4g34215 gene from Arabidopsis thaliana.. Acta Crystallogr D Biol Crystallogr. 61(Pt 12):1655-61.
2006
Pusch M, Zifarelli G, Murgia AR, Picollo A, Babini E.  2006.  Channel or transporter? The CLC saga continues. Exp Physiol. 91(1):149-52.
Porotto M, Fornabaio M, Greengard O, Murrell MT, Kellogg GE, Moscona A.  2006.  Paramyxovirus receptor-binding molecules: engagement of one site on the hemagglutinin-neuraminidase protein modulates activity at the second site.. J Virol. 80(3):1204-13.
McCoy JG, Arabshahi A, Bitto E, Bingman CA, Ruzicka FJ, Frey PA, Phillips GN.  2006.  Structure and mechanism of an ADP-glucose phosphorylase from Arabidopsis thaliana.. Biochemistry. 45(10):3154-62.
McCoy JG, Bailey LJ, Bitto E, Bingman CA, Aceti DJ, Fox BG, Phillips GN.  2006.  Structure and mechanism of mouse cysteine dioxygenase.. Proc Natl Acad Sci U S A. 103(9):3084-9.
McCoy JG, Bingman CA, Bitto E, Holdorf MM, Makaroff CA, Phillips GN.  2006.  Structure of an ETHE1-like protein from Arabidopsis thaliana.. Acta Crystallogr D Biol Crystallogr. 62(Pt 9):964-70.
Bitto E, Bingman CA, Wesenberg GE, McCoy JG, Phillips GN.  2006.  Structure of pyrimidine 5'-nucleotidase type 1. Insight into mechanism of action and inhibition during lead poisoning.. J Biol Chem. 281(29):20521-9.
2007
Naguib M, Gottumukkala V, Goldstein PA.  2007.  Melatonin and anesthesia: a clinical perspective.. J Pineal Res. 42(1):12-21.
Hemmings HC.  2007.  Noble meets nouveau: a shared anesthetic binding site for xenon and isoflurane on a glutamate receptor.. Anesthesiology. 107(5):694-6.
McCoy JG, Bitto E, Bingman CA, Wesenberg GE, Bannen RM, Kondrashov DA, Phillips GN.  2007.  Structure and dynamics of UDP-glucose pyrophosphorylase from Arabidopsis thaliana with bound UDP-glucose and UTP.. J Mol Biol. 366(3):830-41.
2008
Levin EJ, Elsen NL, Seder KD, McCoy JG, Fox BG, Phillips GN.  2008.  X-ray structure of a soluble Rieske-type ferredoxin from Mus musculus.. Acta Crystallogr D Biol Crystallogr. 64(Pt 9):933-40.
2009
Picollo A, Malvezzi M, Houtman JCD, Accardi A.  2009.  Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters.. Nat Struct Mol Biol. 16(12):1294-301.
Thompson AN, Kim I, Panosian TD, Iverson TM, Allen TW, Nimigean CM.  2009.  Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore.. Nat Struct Mol Biol. 16(12):1317-24.
2010
Accardi A, Picollo A.  2010.  CLC channels and transporters: proteins with borderline personalities.. Biochim Biophys Acta. 1798(8):1457-64.
Zifarelli G, Liantonio A, Gradogna A, Picollo A, Gramegna G, De Bellis M, Murgia AR, Babini E, D Camerino C, Pusch M.  2010.  Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels.. Br J Pharmacol. 160(7):1652-61.
Picollo A, Malvezzi M, Accardi A.  2010.  Proton block of the CLC-5 Cl-/H+ exchanger.. J Gen Physiol. 135(6):653-9.
Gradogna A, Babini E, Picollo A, Pusch M.  2010.  A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.. J Gen Physiol. 136(3):311-23.
2012
Zhu J, Choi W-S, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D et al..  2012.  Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS.. Sci Transl Med. 4(125):125ra32.
2014
Corral-Rodríguez MÁngeles, Stuiver M, Abascal-Palacios G, Diercks T, Oyenarte I, Ereño-Orbea J, de Opakua AIbáñez, Blanco FJ, Encinar JAntonio, Spiwok V et al..  2014.  Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.. Biochem J. 464(1):23-34.