Department of Anesthesiology
Author Title Type [ Year(Desc)]
Filters: Author is Accardi, Alessio  [Clear All Filters]
2015
Basilio D, Accardi A.  2015.  A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters.. J Vis Exp. (98)
Accardi A.  2015.  Structure and gating of CLC channels and exchangers.. J Physiol. 593(18):4129-38.
Picollo A, Malvezzi M, Accardi A.  2015.  TMEM16 proteins: unknown structure and confusing functions.. J Mol Biol. 427(1):94-105.
2016
Lee B-C, Menon AK, Accardi A.  2016.  The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel.. Biophys J. 111(9):1919-1924.
2017
Vien M, Basilio D, Leisle L, Accardi A.  2017.  Probing the conformation of a conserved glutamic acid within the Cl(-) pathway of a CLC H(+)/Cl(-) exchanger.. J Gen Physiol. 149(4):523-529.
2018
Lee B-C, Khelashvili G, Falzone M, Menon AK, Weinstein H, Accardi A.  2018.  Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase.. Nat Commun. 9(1):3251.
Falzone ME, Malvezzi M, Lee B-C, Accardi A.  2018.  Known structures and unknown mechanisms of TMEM16 scramblases and channels.. J Gen Physiol.
Malvezzi M, Andra KK, Pandey K, Lee B-C, Falzone ME, Brown A, Iqbal R, Menon AK, Accardi A.  2018.  Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases.. Proc Natl Acad Sci U S A. 115(30):E7033-E7042.
2019
Khelashvili G, Falzone ME, Cheng X, Lee B-C, Accardi A, Weinstein H.  2019.  Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca-bound nhTMEM16.. Nat Commun. 10(1):4972.
2020
Khelashvili G, Cheng X, Falzone ME, Doktorova M, Accardi A, Weinstein H.  2020.  Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins.. J Comput Chem. 41(6):538-551.
2021
Fortea E, Accardi A.  2021.  A quantitative flux assay for the study of reconstituted Cl- channels and transporters.. Methods Enzymol. 652:243-272.
2022
Leisle L, Lam K, Dehghani-Ghahnaviyeh S, Fortea E, Galpin JD, Ahern CA, Tajkhorshid E, Accardi A.  2022.  Backbone amides are determinants of Cl- selectivity in CLC ion channels.. Nat Commun. 13(1):7508.
2024
Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftci HDidar, Falzone ME, Huysmans G, Robertson JL et al..  2024.  Author Correction: Structural basis of pH-dependent activation in a CLC transporter.. Nat Struct Mol Biol.
Feng Z, Di Zanni E, Alvarenga O, Chakraborty S, Rychlik N, Accardi A.  2024.  In or out of the groove? Mechanisms of lipid scrambling by TMEM16 proteins. Cell Calcium. 121:102896.
Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, H Larsson P et al..  2024.  Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.. Nature.
Feng Z, Alvarenga OE, Accardi A.  2024.  Structural basis of closed groove scrambling by a TMEM16 protein.. Nat Struct Mol Biol.
Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftici D, Falzone ME, Huysmans G, Robertson JL et al..  2024.  Structural basis of pH-dependent activation in a CLC transporter.. Nat Struct Mol Biol.
Chakraborty S, Feng Z, Lee S, Alvarenga OE, Panda A, Bruni R, Khelashvili G, Gupta K, Accardi A.  2024.  Structure and function of the human apoptotic scramblase Xkr4.. bioRxiv.
2025
Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM.  2025.  Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel.. Nat Commun. 16(1):1769.