Department of Anesthesiology

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Effect of massive intraoperative thiopental loading on cardiovascular hemodynamics and myocardial performance.

TitleEffect of massive intraoperative thiopental loading on cardiovascular hemodynamics and myocardial performance.
Publication TypeJournal Article
Year of Publication1991
AuthorsStone JG, Young WL, Khambatta HJ, Lien CA, Hsu DT, Solomon RA, Smith CR
JournalJ Neurosurg Anesthesiol
Volume3
Issue2
Pagination132-5
Date Published1991 Jun
ISSN0898-4921
Abstract

Anesthetics that protect the brain may also depress the heart. We recently anesthetized a patient with a giant cerebral aneurysm of the basilar artery who had it clipped during circulatory arrest. Thiopental loading was carried out prior to and during cardiopulmonary bypass, and we monitored transesophageal echocardiographic function and the hemodynamic profile throughout. The patient demonstrated little change in cardiovascular parameters or myocardial performance, and we conclude that the massive dose of thiopental was well tolerated.

Alternate JournalJ Neurosurg Anesthesiol
PubMed ID15815392