Department of Anesthesiology

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Dopamine- and adenosine-3':5'-monophosphate (cAMP)-regulated phosphoprotein of Mr 32,000 (DARPP-32) in the retina of cat, monkey and human.

TitleDopamine- and adenosine-3':5'-monophosphate (cAMP)-regulated phosphoprotein of Mr 32,000 (DARPP-32) in the retina of cat, monkey and human.
Publication TypeJournal Article
Year of Publication1991
AuthorsMeister B, Arvidsson U, Hemmings HC, Greengard P, Hökfelt T
JournalNeurosci Lett
Volume131
Issue1
Pagination66-70
Date Published1991 Sep 30
ISSN0304-3940
KeywordsAnimals, Antibodies, Monoclonal, Cats, Dopamine and cAMP-Regulated Phosphoprotein 32, Fluorescent Antibody Technique, Humans, Macaca fascicularis, Nerve Tissue Proteins, Phosphoproteins, Photoreceptor Cells, Retina, Species Specificity
Abstract

The cellular localization of a dopamine- and cAMP-regulated phosphoprotein of Mr 32,000 (DARPP-32) was investigated in cat, monkey and human retina by immunohistochemistry. In cat, DARPP-32-immunoreactive cell bodies identified as Müller cells were demonstrated in the inner nuclear layer (INL) with processes closely surrounding the cell soma of photoreceptors in the outer nuclear layer. Some DARPP-32-IR cells were also seen in the nerve fiber layer (NFL) sending processes to the inner plexiform layer. In monkey and human retina, DARPP-32-IR cell bodies were also demonstrated in the INL, with few cells located in the NFL.

Alternate JournalNeurosci. Lett.
PubMed ID1791981
Grant ListMH40899 / MH / NIMH NIH HHS / United States
MH43230 / MH / NIMH NIH HHS / United States